Abstract

Our work can be divided into three major categories: functional neuroanatomy, molecular neuroendocrinology, and behavior. Mapping receptor localizations using autoradiography has provided important basic information about brain organization and function. We have localized the cannabinoid receptor in brain. In situ hybridization is used to examine the regulation of gene expression in neuropeptides, monoamine synthesizing enzymes, and adrenal steroid receptors. Molecular neuroanatomical techniques are used to elucidate brain mechanisms involved in stress, food restriction, and chronic antidepressant drug treatment. Behavioral studies are designed to assess behavioral and biochemical factors associated with anti-anxiety drug withdrawal, stress, restricted food intake, and consequences of central administration of neuroendocrine factors in primates. Many of these studies focus on the role of corticotropin releasing hormone (CRH) in the pathophysiology of affective disorder.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH001090-14
Application #
3859862
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
14
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Lehmann, Michael L; Mustafa, Tomris; Eiden, Adrian M et al. (2013) PACAP-deficient mice show attenuated corticosterone secretion and fail to develop depressive behavior during chronic social defeat stress. Psychoneuroendocrinology 38:702-15
Patchev, Alexandre V; Fischer, Dieter; Wolf, Siegmund S et al. (2007) Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF-2 deficient mice. FASEB J 21:231-8
Steiner, Alexandre A; Chakravarty, Sumana; Rudaya, Alla Y et al. (2006) Bacterial lipopolysaccharide fever is initiated via Toll-like receptor 4 on hematopoietic cells. Blood 107:4000-2
Chakravarty, Sumana; Herkenham, Miles (2005) Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines. J Neurosci 25:1788-96
Steiner, Alexandre A; Chakravarty, Sumana; Robbins, Jared R et al. (2005) Thermoregulatory responses of rats to conventional preparations of lipopolysaccharide are caused by lipopolysaccharide per se-- not by lipoprotein contaminants. Am J Physiol Regul Integr Comp Physiol 289:R348-R352
Herkenham, Miles (2005) Folliculo-stellate (FS) cells of the anterior pituitary mediate interactions between the endocrine and immune systems. Endocrinology 146:33-4
Bryceson, Y T; Foster, J A; Kuppusamy, S P et al. (2005) Expression of a killer cell receptor-like gene in plastic regions of the central nervous system. J Neuroimmunol 161:177-82
Kassed, Cheryl A; Herkenham, Miles (2004) NF-kappaB p50-deficient mice show reduced anxiety-like behaviors in tests of exploratory drive and anxiety. Behav Brain Res 154:577-84
Foster, Jane A; Puchowicz, Michael J; McIntyre, Dan C et al. (2004) Activin mRNA induced during amygdala kindling shows a spatiotemporal progression that tracks the spread of seizures. J Comp Neurol 476:91-102
Butterweck, Veronika; Winterhoff, Hilke; Herkenham, Miles (2003) Hyperforin-containing extracts of St John's wort fail to alter gene transcription in brain areas involved in HPA axis control in a long-term treatment regimen in rats. Neuropsychopharmacology 28:2160-8

Showing the most recent 10 out of 29 publications