Disorders of perception, attention, and memory frequently accompany the major mental diseases. To begin to understand the neural mechanisms of these mental processes, we are recording the activity of neurons in the extrastriate cortex of monkeys engaged in tasks requiring visual discrimination, selective attention, and recognition memory. We have found in area V4 of the occipital cortex and area TE of the inferior temporal cortex that selective attention gates visual processing by filtering unwanted information from the receptive fields. Even the degree to which attended stimuli are processed in these areas depends on """"""""how much"""""""" attention or effort is devoted to them. Thus, the information-processing capacity of cortical neurons depends not only on hard-wired mechanisms but on cognitive state. To identify the mechanisms by which cognitive state modulates cortical activity, we have begun to examine both extrastriate neuronal activity and animal behavior in an attention-demanding task following lesions of selective portions of the prefrontal cortex, posterior parietal cortex, limbic- system, and basal ganglia.
| Pitcher, David; Japee, Shruti; Rauth, Lionel et al. (2017) The Superior Temporal Sulcus Is Causally Connected to the Amygdala: A Combined TBS-fMRI Study. J Neurosci 37:1156-1161 |
| Zhang, Hui; Japee, Shruti; Nolan, Rachel et al. (2016) Face-selective regions differ in their ability to classify facial expressions. Neuroimage 130:77-90 |
| Gregoriou, Georgia G; Gotts, Stephen J; Zhou, Huihui et al. (2009) High-frequency, long-range coupling between prefrontal and visual cortex during attention. Science 324:1207-10 |
| Ungerleider, Leslie G; Galkin, Thelma W; Desimone, Robert et al. (2008) Cortical connections of area V4 in the macaque. Cereb Cortex 18:477-99 |
| Berman, Rebecca A; Heiser, Laura M; Dunn, Catherine A et al. (2007) Dynamic circuitry for updating spatial representations. III. From neurons to behavior. J Neurophysiol 98:105-21 |
| Womelsdorf, Thilo; Fries, Pascal; Mitra, Partha P et al. (2006) Gamma-band synchronization in visual cortex predicts speed of change detection. Nature 439:733-6 |
| Bichot, Narcisse P; Desimone, Robert (2006) Finding a face in the crowd: parallel and serial neural mechanisms of visual selection. Prog Brain Res 155:147-56 |
| Schulz, G M; Varga, M; Jeffires, K et al. (2005) Functional neuroanatomy of human vocalization: an H215O PET study. Cereb Cortex 15:1835-47 |
| Bichot, Narcisse P; Rossi, Andrew F; Desimone, Robert (2005) Parallel and serial neural mechanisms for visual search in macaque area V4. Science 308:529-34 |
| Buffalo, Elizabeth A; Bertini, Giuseppe; Ungerleider, Leslie G et al. (2005) Impaired filtering of distracter stimuli by TE neurons following V4 and TEO lesions in macaques. Cereb Cortex 15:141-51 |
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