Animal Models of Neuropsychiatric Disorders

Crawley, J N.

Abstract

1) Our hamster separation model of depression was tested for changes in corticotropin releasing factor, ACTH and cortisol. 2) Mice treated chronically with steroids were tested for hyperactivity of their central dopamine pathways, both behaviorally and biochemically, as a model for steroid-induced psychoses. 3) The central hypothalamic binding site for anorectic drugs such as amphetamine was analyzed for its role in regulation of feeding behaviors. 4) A benzodiazepine which antagonizes the biochemical actions of ethanol in rat brain was found to prevent and reverse ethanol-induced intoxication in rats. 5) Behavioral analysis of rats treated chronically with interleukin-II revealed reductions in exploratory and social behaviors at doses of IL-II analogous to those which induce psychoses when used to treat cancer patients.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Mental Health (NIMH)
• Type: Intramural Research (Z01)
• Project #: 1Z01MH002179-04
• Application #: 3968521
• Support Year: 4
• Fiscal Year: 1986

Institution

• Name: U.S. National Institute of Mental Health
• Country: United States

Publications

Yang, Mu; Silverman, Jill L; Crawley, Jacqueline N (2011) Automated three-chambered social approach task for mice. Curr Protoc Neurosci Chapter 8:Unit 8.26

Silverman, Jill L; Yang, Mu; Lord, Catherine et al. (2010) Behavioural phenotyping assays for mouse models of autism. Nat Rev Neurosci 11:490-502

Scattoni, Maria Luisa; Crawley, Jacqueline; Ricceri, Laura (2009) Ultrasonic vocalizations: a tool for behavioural phenotyping of mouse models of neurodevelopmental disorders. Neurosci Biobehav Rev 33:508-15

McFarlane, H G; Kusek, G K; Yang, M et al. (2008) Autism-like behavioral phenotypes in BTBR T+tf/J mice. Genes Brain Behav 7:152-63

Ricceri, Laura; Moles, Anna; Crawley, Jacqueline (2007) Behavioral phenotyping of mouse models of neurodevelopmental disorders: relevant social behavior patterns across the life span. Behav Brain Res 176:40-52

Crawley, Jacqueline N (2007) Mouse behavioral assays relevant to the symptoms of autism. Brain Pathol 17:448-59

Bailey, Kathleen R; Pavlova, Maria N; Rohde, Alex D et al. (2007) Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze. Pharmacol Biochem Behav 86:8-20

Moy, Sheryl S; Nadler, Jessica J; Young, Nancy B et al. (2007) Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176:4-20

Crawley, Jacqueline N; Chen, Thomas; Puri, Amit et al. (2007) Social approach behaviors in oxytocin knockout mice: comparison of two independent lines tested in different laboratory environments. Neuropeptides 41:145-63

Yang, Mu; Zhodzishsky, Vladimir; Crawley, Jacqueline N (2007) Social deficits in BTBR T+tf/J mice are unchanged by cross-fostering with C57BL/6J mothers. Int J Dev Neurosci 25:515-21