Abstract

In situ hybridization analysis of mRNAs for tyrosine hydroxylase, cholecystokinin, enkephalin, the D-1 and D-2 dopamine receptor subtypes, and the dopamine transporter, in brains from rats treated neonatally with cocaine, are almost completed. No difference between cocaine treatment and dietary controls has been seen in mRNA concentrations in the ventral tegmentum, substantia nigra, caudate nucleus, or nucleus accumbens, for TH, CCK, ENK, D-1, or D-2 mRNAs. Dr. de Bartolomeis has recently developed a new oligonucleotide probe for the dopamine transporter, which he has characterized for specificity, and is now quantitating in the prenatal cocaine experiment.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002179-10
Application #
3845218
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Yang, Mu; Silverman, Jill L; Crawley, Jacqueline N (2011) Automated three-chambered social approach task for mice. Curr Protoc Neurosci Chapter 8:Unit 8.26
Silverman, Jill L; Yang, Mu; Lord, Catherine et al. (2010) Behavioural phenotyping assays for mouse models of autism. Nat Rev Neurosci 11:490-502
Scattoni, Maria Luisa; Crawley, Jacqueline; Ricceri, Laura (2009) Ultrasonic vocalizations: a tool for behavioural phenotyping of mouse models of neurodevelopmental disorders. Neurosci Biobehav Rev 33:508-15
McFarlane, H G; Kusek, G K; Yang, M et al. (2008) Autism-like behavioral phenotypes in BTBR T+tf/J mice. Genes Brain Behav 7:152-63
Ricceri, Laura; Moles, Anna; Crawley, Jacqueline (2007) Behavioral phenotyping of mouse models of neurodevelopmental disorders: relevant social behavior patterns across the life span. Behav Brain Res 176:40-52
Crawley, Jacqueline N (2007) Mouse behavioral assays relevant to the symptoms of autism. Brain Pathol 17:448-59
Bailey, Kathleen R; Pavlova, Maria N; Rohde, Alex D et al. (2007) Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze. Pharmacol Biochem Behav 86:8-20
Moy, Sheryl S; Nadler, Jessica J; Young, Nancy B et al. (2007) Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176:4-20
Crawley, Jacqueline N; Chen, Thomas; Puri, Amit et al. (2007) Social approach behaviors in oxytocin knockout mice: comparison of two independent lines tested in different laboratory environments. Neuropeptides 41:145-63
Yang, Mu; Zhodzishsky, Vladimir; Crawley, Jacqueline N (2007) Social deficits in BTBR T+tf/J mice are unchanged by cross-fostering with C57BL/6J mothers. Int J Dev Neurosci 25:515-21

Showing the most recent 10 out of 32 publications