Abstract

Dr. Paylor has identified inbred strains of mice that are very high (AKR) and very low (C57BL/6J) on Prepulse Inhibition (PPI). PPI is a measure of sensorimotor gating which is abnormal in several neuropsychiatric disorders, including schizophrenia. Poor PPI in C57BL/6J mice may provide an animal model of the deficit on prepulse inhibition seen in schizophrenia. Breeding of the AKR x C57BL/6J cross produced F2 mice, for Quantitative Trait Loci analysis of genes linked to schizophrenia-like symptoms on Prepulse Inhibition. Behavioral testing of 500 F2 mice was completed this year by Dr. Paylor and Ms. Libbey. Genotyping of the extremes of the 500 F2 mice is now in progress. Our Section collaborates with molecular geneticists in NIMH and other NIH IRPs on behavioral phenotyping of transgenic and knockout mice with mutations of genes expressed in the brain. Several of these small pilot collaborations have revealed major behavioral phenotypes relevant to mental illnesses, including PPI deficits in mice with mutations in the serotonin transporter, and in a developmental gene, dishevelled-1.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002179-12
Application #
6162859
Study Section
Special Emphasis Panel (ETB)
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Yang, Mu; Silverman, Jill L; Crawley, Jacqueline N (2011) Automated three-chambered social approach task for mice. Curr Protoc Neurosci Chapter 8:Unit 8.26
Silverman, Jill L; Yang, Mu; Lord, Catherine et al. (2010) Behavioural phenotyping assays for mouse models of autism. Nat Rev Neurosci 11:490-502
Scattoni, Maria Luisa; Crawley, Jacqueline; Ricceri, Laura (2009) Ultrasonic vocalizations: a tool for behavioural phenotyping of mouse models of neurodevelopmental disorders. Neurosci Biobehav Rev 33:508-15
McFarlane, H G; Kusek, G K; Yang, M et al. (2008) Autism-like behavioral phenotypes in BTBR T+tf/J mice. Genes Brain Behav 7:152-63
Ricceri, Laura; Moles, Anna; Crawley, Jacqueline (2007) Behavioral phenotyping of mouse models of neurodevelopmental disorders: relevant social behavior patterns across the life span. Behav Brain Res 176:40-52
Crawley, Jacqueline N (2007) Mouse behavioral assays relevant to the symptoms of autism. Brain Pathol 17:448-59
Bailey, Kathleen R; Pavlova, Maria N; Rohde, Alex D et al. (2007) Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze. Pharmacol Biochem Behav 86:8-20
Moy, Sheryl S; Nadler, Jessica J; Young, Nancy B et al. (2007) Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains. Behav Brain Res 176:4-20
Crawley, Jacqueline N; Chen, Thomas; Puri, Amit et al. (2007) Social approach behaviors in oxytocin knockout mice: comparison of two independent lines tested in different laboratory environments. Neuropeptides 41:145-63
Yang, Mu; Zhodzishsky, Vladimir; Crawley, Jacqueline N (2007) Social deficits in BTBR T+tf/J mice are unchanged by cross-fostering with C57BL/6J mothers. Int J Dev Neurosci 25:515-21

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