Abstract

Postmortem Studies in neuropsychiatric disorders test hypotheses with regard to schizophrenia, suicide, Parkinson's Disease, addictions and aging. New findings include the following: Decreased the numbers of D-1 dopamine receptors with increased affinity in schizophrenic patients in the caudate nucleus as compared with controls; (2) No evidence for transmission of viruses from schizophrenic brain specimens to controls; (3) Little evidence for lateralization of neuropeptides (somatostatin, and vasopressin, oxytocin) in schizophrenic brain samples and; (4) decreased dopamine reuptake binding in Parkinson's patients versus controls.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002399-01
Application #
3944828
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Kaalund, S S; Newburn, E N; Ye, T et al. (2014) Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain. Mol Psychiatry 19:1258-66
Hyde, Thomas M; Lipska, Barbara K; Ali, Towhid et al. (2011) Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia. J Neurosci 31:11088-95
Bigos, Kristin L; Mattay, Venkata S; Callicott, Joseph H et al. (2010) Genetic variation in CACNA1C affects brain circuitries related to mental illness. Arch Gen Psychiatry 67:939-45
Montague, D; Weickert, C S; Tomaskovic-Crook, E et al. (2008) Oestrogen receptor alpha localisation in the prefrontal cortex of three mammalian species. J Neuroendocrinol 20:893-903
Weickert, Cynthia Shannon; Rothmond, Debora A; Hyde, Thomas M et al. (2008) Reduced DTNBP1 (dysbindin-1) mRNA in the hippocampal formation of schizophrenia patients. Schizophr Res 98:105-10
Straub, R E; Lipska, B K; Egan, M F et al. (2007) Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression. Mol Psychiatry 12:854-69
Mathew, Shiny V; Law, Amanda J; Lipska, Barbara K et al. (2007) Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1. Hum Mol Genet 16:2921-32
Tseng, Kuei-Yuan; Lewis, Barbara L; Lipska, Barbara K et al. (2007) Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia. Biol Psychiatry 62:730-8
Tunbridge, E M; Weickert, C S; Kleinman, J E et al. (2007) Catechol-o-methyltransferase enzyme activity and protein expression in human prefrontal cortex across the postnatal lifespan. Cereb Cortex 17:1206-12
Perlman, William R; Webster, Maree J; Herman, Mary M et al. (2007) Age-related differences in glucocorticoid receptor mRNA levels in the human brain. Neurobiol Aging 28:447-58

Showing the most recent 10 out of 73 publications