Our research program has two main components. Firstly, to develop and test models of cognitive processes via study of the way these processes breakdown following brain injury or disease. Secondly, to evaluate the cognitive status of psychiatric patients in order to test hypotheses concerning possible neuroanatomic correlates of these disorders. Our studies have utilized priming paradigms that place minimal demands on attentional and retrieval processes to assess the integrity of object recognition, naming, visuospatial processes and memory in patients with Alzheimer's disease. We have obtained evidence in support of a model that posits that posterior cortical pathology results in a selective degradation of previously acquired knowledge, rather than an inability to retrieve information from intact knowledge stores. These degraded knowledge representations are, in turn, proposed to be responsible for impaired naming and to substantially contribute to poor memory in patients with Alzheimer's disease. Our studies of relatively early-stage, medically asymptomatic individuals infected with the Human Immunodeficiency Virus (HIV) have found slowed response times, impaired motor-skill learning and other subtle deficits consistent with involvement of subcortical regions of the brain in a subgroup of subjects. The significant relationship between task performance and concentrations of a potent neurotoxin, quinolinic acid, in the cerebral spinal fluid of the HIV+ subjects, suggested that the deficits may be primarily due to infection of the CNS. The presence of diffuse EEG slowing and the finding that cognitive dysfunction in these individuals was unrelated to mood changes, provided additional evidence for CNS involvment in these subjects.
| Bellgowan, Patrick S F; Buffalo, Elizabeth A; Bodurka, Jerzy et al. (2009) Lateralized spatial and object memory encoding in entorhinal and perirhinal cortices. Learn Mem 16:433-8 |
| Simmons, W Kyle; Reddish, Mark; Bellgowan, Patrick S F et al. (2009) The Selectivity and Functional Connectivity of the Anterior Temporal Lobes. Cereb Cortex : |
| Mahon, Bradford Z; Milleville, Shawn C; Negri, Gioia A L et al. (2007) Action-related properties shape object representations in the ventral stream. Neuron 55:507-20 |
| Wheatley, Thalia; Milleville, Shawn C; Martin, Alex (2007) Understanding animate agents: distinct roles for the social network and mirror system. Psychol Sci 18:469-74 |
| Simmons, W Kyle; Bellgowan, Patrick S F; Martin, Alex (2007) Measuring selectivity in fMRI data. Nat Neurosci 10:4-5 |
| Simmons, W Kyle; Ramjee, Vimal; Beauchamp, Michael S et al. (2007) A common neural substrate for perceiving and knowing about color. Neuropsychologia 45:2802-10 |
| Martin, Alex (2007) The representation of object concepts in the brain. Annu Rev Psychol 58:25-45 |
| Weisberg, Jill; van Turennout, Miranda; Martin, Alex (2007) A neural system for learning about object function. Cereb Cortex 17:513-21 |
| Buffalo, Elizabeth A; Bellgowan, Patrick S F; Martin, Alex (2006) Distinct roles for medial temporal lobe structures in memory for objects and their locations. Learn Mem 13:638-43 |
| Luo, Qian; Nakic, Marina; Wheatley, Thalia et al. (2006) The neural basis of implicit moral attitude--an IAT study using event-related fMRI. Neuroimage 30:1449-57 |
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