Abstract

A two to five year prospective follow-up of 54 children and adolescents with obsessive compulsive disorder (OCD) revealed that, as a group, there was significant improvement from baseline. A subgroup of children had an episodic course punctuated by periods of abrupt symptom exacerbation and gradual remission. In addition, prospective systematic examination of children with Sydenham's Chorea (SC), (a variant of rheumatic fever), demonstrated that OC symptoms were present concomitantly with the onset of the movement disorder and were associated with the presence of antineuronal antibodies. Taken together, these suggested that a group of antineuronal antibody-mediated neuropsychiatric disorders might exist. One major thrust of our research is to determine the frequency and etiology of such disorders in order to establish effective intervention and prevention strategies. Other investigations include an ongoing activated PET (O15)study of OCD and its components, as well as drug-treatment studies of obsessive- compulsive """"""""spectrum"""""""" disorders such as stuttering, and self-injurious and/or repetitive behaviors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002666-02
Application #
3759527
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Kalra, Simran K; Swedo, Susan E (2009) Children with obsessive-compulsive disorder: are they just ""little adults""? J Clin Invest 119:737-46
Murphy, Tanya K; Snider, Lisa A; Mutch, P Jane et al. (2007) Relationship of movements and behaviors to Group A Streptococcus infections in elementary school children. Biol Psychiatry 61:279-84
Grant, Paul; Lougee, Lorraine; Hirschtritt, Matthew et al. (2007) An open-label trial of riluzole, a glutamate antagonist, in children with treatment-resistant obsessive-compulsive disorder. J Child Adolesc Psychopharmacol 17:761-7
Kirvan, Christine A; Cox, Carol J; Swedo, Susan E et al. (2007) Tubulin is a neuronal target of autoantibodies in Sydenham's chorea. J Immunol 178:7412-21
Stein, Dan J; Arya, Monisha; Pietrini, Pietro et al. (2006) Neurocircuitry of disgust and anxiety in obsessive-compulsive disorder: a positron emission tomography study. Metab Brain Dis 21:267-77
Kirvan, Christine A; Swedo, Susan E; Kurahara, David et al. (2006) Streptococcal mimicry and antibody-mediated cell signaling in the pathogenesis of Sydenham's chorea. Autoimmunity 39:21-9
Kirvan, Christine A; Swedo, Susan E; Snider, Lisa A et al. (2006) Antibody-mediated neuronal cell signaling in behavior and movement disorders. J Neuroimmunol 179:173-9
Snider, Lisa A; Lougee, Lorraine; Slattery, Marcia et al. (2005) Antibiotic prophylaxis with azithromycin or penicillin for childhood-onset neuropsychiatric disorders. Biol Psychiatry 57:788-92
Swedo, Susan E; Grant, Paul J (2005) Annotation: PANDAS: a model for human autoimmune disease. J Child Psychol Psychiatry 46:227-34
Asbahr, Fernando R; Garvey, Marjorie A; Snider, Lisa A et al. (2005) Obsessive-compulsive symptoms among patients with Sydenham chorea. Biol Psychiatry 57:1073-6

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