We have developed a variety of tasks to activate regions of interest in functional neuroimaging studies. 1. To examine the distinction between recall and familiarity in episodic memory function we have developed a task using visual scenes that reliably induces familiarity based errors in controls. 2. We assessed the role of Catecol-O-methyltransferase(COMT) genotype in a functional Magnetic Resonance Imaging (fMRI) event related study which gauged the effects of cognitive control on various conditions involving interference in the so called flanker task. 3. We developed a carefully matched set of verbal fluency tasks to examine the relation between semantic processing, thought disorder, and neurophysiology in schizophrenia using PET CBF (Positron Emission Tomography Cerebral Blood Flow) methods. We found an area in inferior prefrontal cortex (PFC) that was more activated in semantic fluency and correlated with a classic symptom of schizophrenia -- thought disorder. 4. We are using a novel updating task which allows the amount of """"""""updating"""""""" to be varied parametrically by demanding operations on single or multiple frames within each trial. This technique will allow us to examine whether there is an interaction between load and delay in the dorsolateral prefrontal cortex and how and whether such interactions may engage different subdivisions within the prefrontal cortex.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Intramural Research (Z01)
Project #
1Z01MH002711-10
Application #
6980323
Study Section
(CBDB)
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2004
Total Cost
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Diaz-Asper, Catherine M; Weinberger, Daniel R; Goldberg, Terry E (2006) Catechol-O-methyltransferase polymorphisms and some implications for cognitive therapeutics. NeuroRx 3:97-105
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Foltynie, Thomas; Lewis, Simon G J; Goldberg, Terry E et al. (2005) The BDNF Val66Met polymorphism has a gender specific influence on planning ability in Parkinson's disease. J Neurol 252:833-8
Weickert, Thomas W; Goldberg, Terry E (2005) First- and second-generation antipsychotic medication and cognitive processing in schizophrenia. Curr Psychiatry Rep 7:304-10

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