Intramural Statistical Collaboration and Consultation

Dambrosia, J M.

Abstract

This project is designed to provide statistical collaboration and consultation for Laboratories and Branches within the Intramural Research Program. Particular consideration is given to statistical planning and design of experiments, statistical analysis of data, and statistical inference. Our collaboration has involved eight laboratories/branches, and the scope of the studies has ranged from the coordination and statistical management of a complex clinical trial to consultation on the correctness of the statistics used for small laboratory experiments. Examples of studies in the IRP include a randomized clinical trial of W-544, a new drug for the treatment of intractable partial seizures (CMN); an evaluation of efficacy of the drug PGBX for treatment of ischemic stroke in a gerbil model (LNNS and LN); a statistical examination of space-time clustening of Creutzfeldt-Jakob disease in a defined population (LCNSS); an examination of the relation of polio viruses to Alzheimer's disease (LCNSS); a study of the relationship of viral antibodies to MS (ID); and a study of the dopaminergic modulation of DES-induced proliferation of the anterior pituitary gland of the Fisher 344 rat (ET), and the effect of calcium channel modifiers on prolactin release (ET).

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Neurological Disorders and Stroke (NINDS)
• Type: Intramural Research (Z01)
• Project #: 1Z01NS002652-01
• Application #: 4696955
• Support Year: 1
• Fiscal Year: 1985

Institution

• Name: National Institute of Neurological Disorders and Stroke
• Country: United States

Publications

Nelson, Karin B; Grether, Judith K; Dambrosia, James M et al. (2003) Neonatal cytokines and cerebral palsy in very preterm infants. Pediatr Res 53:600-7

Schiffmann, Raphael; Mankin, Henry; Dambrosia, James M et al. (2002) Decreased bone density in splenectomized Gaucher patients receiving enzyme replacement therapy. Blood Cells Mol Dis 28:288-96

Zeuner, Kirsten E; Bara-Jimenez, William; Noguchi, Patricia S et al. (2002) Sensory training for patients with focal hand dystonia. Ann Neurol 51:593-8

Mittendorf, Robert; Dambrosia, James; Pryde, Peter G et al. (2002) Association between the use of antenatal magnesium sulfate in preterm labor and adverse health outcomes in infants. Am J Obstet Gynecol 186:1111-8

Mittendorf, Robert; Dambrosia, James; Dammann, Olaf et al. (2002) Association between maternal serum ionized magnesium levels at delivery and neonatal intraventricular hemorrhage. J Pediatr 140:540-6

Nelson, K B; Grether, J K; Croen, L A et al. (2001) Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation. Ann Neurol 49:597-606

Altarescu, G M; Goldfarb, L G; Park, K Y et al. (2001) Identification of fifteen novel mutations and genotype-phenotype relationship in Fabry disease. Clin Genet 60:46-51

Altarescu, G; Hill, S; Wiggs, E et al. (2001) The efficacy of enzyme replacement therapy in patients with chronic neuronopathic Gaucher's disease. J Pediatr 138:539-47

Baird, A E; Dambrosia, J; Janket, S et al. (2001) A three-item scale for the early prediction of stroke recovery. Lancet 357:2095-9

Spanaki, M V; Kopylev, L; DeCarli, C et al. (2000) Postoperative changes in cerebral metabolism in temporal lobe epilepsy. Arch Neurol 57:1447-52