Current studies in the Cognitive Neuroscience Section focus on planning, thinking, and reasoning; memory and amnesia; visual attention, spatial perception, and object recognition; and emotion/social cognition. Both single-case and group design studies are used. Normal controls, inpatients, and outpatients with central nervous system impairment are recruited for studies. Planning, thinking and reasoning are studied in experiments focusing on schema development, the generation of cognitive plans, analogical thinking, script event generation and verification, number processing and calculation, knowledge representation, and divided resources. Memory and amnesia is studied in experiments focusing on implicit and explicit encoding and retrieval, priming, autobiographic recall, discourse processing, naming and word retrieval, and categorization tasks. Visual attention, spatial perception, and object recognition are studied in experiments focusing on spatial frequency, contrast sensitivity, object knowledge and feature verification, visual- spatial localization, spatial, selective, and sustained attention, and local-global properties of stimuli. Emotion and social cognition are studied in conjunction with cognitive experiments examining attention and memory, rule retrieval, and inhibition. The development of theoretically valid and testable models of cognitive processing is a primary aim of the Section. We study patients with focal and degenerative lesions in order to topographically map components of cognitive processing to brain regions and systems. Pharmacologic challenge and infusion studies are done to evaluate the dissociability of hypothesized components of cognitive processing. Transcranial magnetic stimulation, functional magnetic resonance imaging, positron emission tomography, and event- related brain potentials are all employed to examine the topographic location and computational properties of cognitive components.
| Goel, Vinod; Lam, Elaine; Smith, Kathleen W et al. (2017) Lesions to polar/orbital prefrontal cortex selectively impair reasoning about emotional material. Neuropsychologia 99:236-245 |
| Zhong, Wanting; Cristofori, Irene; Bulbulia, Joseph et al. (2017) Biological and cognitive underpinnings of religious fundamentalism. Neuropsychologia 100:18-25 |
| Barbey, Aron K; Colom, Roberto; Grafman, Jordan (2013) Architecture of cognitive flexibility revealed by lesion mapping. Neuroimage 82:547-54 |
| Koenigs, Michael; Huey, Edward D; Raymont, Vanessa et al. (2008) Focal brain damage protects against post-traumatic stress disorder in combat veterans. Nat Neurosci 11:232-7 |
| Schooler, Carmi; Caplan, Leslie J; Revell, Andrew J et al. (2008) Brain lesion and memory functioning: short-term memory deficit is independent of lesion location. Psychon Bull Rev 15:521-7 |
| Zamboni, G; Huey, E D; Krueger, F et al. (2008) Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates. Neurology 71:736-42 |
| Krueger, Frank; McCabe, Kevin; Moll, Jorge et al. (2007) Neural correlates of trust. Proc Natl Acad Sci U S A 104:20084-9 |
| Solomon, Jeffrey; Raymont, Vanessa; Braun, Allen et al. (2007) User-friendly software for the analysis of brain lesions (ABLe). Comput Methods Programs Biomed 86:245-54 |
| Zahn, Roland; Moll, Jorge; Krueger, Frank et al. (2007) Social concepts are represented in the superior anterior temporal cortex. Proc Natl Acad Sci U S A 104:6430-5 |
| Frattali, Carol; Hanna, Rebecca; McGinty, Anita Shukla et al. (2007) Effect of prefrontal cortex damage on resolving lexical ambiguity in text. Brain Lang 102:99-113 |
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