We are performing case-control studies within a population-based registry of children with cerebral palsy (CP) born between 1983-1985 in northern California, and a new cohort of very low birthweight children born 1988-1994. Work done in FY99 included:(a) with collaboration from Dr.JM Dambrosia (BFSB) and Dr.TM Phillips of George Washington University, a paper on interferon concentrations in archived neonatal blood of children with CP and controls [published].(b) a study of criteria for selection of neonates to receive neuroprotective therapies as applied to a population [published];(c) a paper on intrauterine exposure to magnesium sulfate used in an attempt to prevent premature birth, and risk of CP in premature infants [submitted];(d) an editorial [published] and two invited reviews [one in press, one in progress]. Studies underway include analyses of clinical, placental histologic, and bacteriologic data as risk factors for CP in premature infants in the new birth cohort, and investigation of cytokines, neuropeptides, and other factors in archived neonatal blood of children with autism, serious mental retardation, or CP. - cerebral palsy, ultramicroimmunoassay, interferons, neonatal, encephalopathy, infection, inflammation, coagulation - Human Subjects & Human Subjects: Interview, Questionaires, or Surveys Only
| Hankins, Gary D V; MacLennan, Alastair H; Speer, Michael E et al. (2006) Obstetric litigation is asphyxiating our maternity services. Obstet Gynecol 107:1382-5 |
| Nelson, Karin B; Leviton, Alan (2006) Hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 354:1643-5; author reply 1643-5 |
| Lynch, John Kylan; Han, Christina J; Nee, Linda E et al. (2005) Prothrombotic factors in children with stroke or porencephaly. Pediatrics 116:447-53 |
| Wu, Yvonne W; Lynch, John K; Nelson, Karin B (2005) Perinatal arterial stroke: understanding mechanisms and outcomes. Semin Neurol 25:424-34 |
| Nelson, Karin B (2005) Neonatal encephalopathy: etiology and outcome. Dev Med Child Neurol 47:292 |
| Nelson, Karin B; Dambrosia, James M; Iovannisci, David M et al. (2005) Genetic polymorphisms and cerebral palsy in very preterm infants. Pediatr Res 57:494-9 |
| Nelson, Karin B; Lynch, John K (2004) Stroke in newborn infants. Lancet Neurol 3:150-8 |
| Grether, Judith K; Nelson, Karin B; Walsh, Eileen et al. (2003) Intrauterine exposure to infection and risk of cerebral palsy in very preterm infants. Arch Pediatr Adolesc Med 157:26-32 |
| Nelson, Karin B (2003) Can we prevent cerebral palsy? N Engl J Med 349:1765-9 |
| Lynch, John Kylan; Hirtz, Deborah G; DeVeber, Gabrielle et al. (2002) Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke. Pediatrics 109:116-23 |
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