We published this year an investigation of concentrations of total protein and of certain neurotrophins, neuropeptides, and cytokines in neonatal blood of children with Down syndrome or autism, and examining the developmental trajectory of these substances in the blood of very premature infants, term infants, and healthy adults recruited from the Blood Bank of NIH. Blood concentrations of brain derived neurotrophic factor increased with age, while neurotrophins -3 and -4/5 concentrations were lower in adults than in newborn infants. Values of interleukin-8 were highest in the newborn period, and were higher in infants with Down syndrome than in controls. No differences between infants with later diagnosis of autism vs. controls were observed. Using specimens from a population-based study in South Australia and analyses by the Laboratory of Molecular Technology, NCI, we are now examining the association of these and other SNPs with CP across the gestational age spectrum, with the collaboration of Dr. Alastair MacLennan. The association of genotype with preterm birth has been explored in this material and a manuscript (Genetic polymorphisms and spontaneous preterm birth) submitted.
| Hankins, Gary D V; MacLennan, Alastair H; Speer, Michael E et al. (2006) Obstetric litigation is asphyxiating our maternity services. Obstet Gynecol 107:1382-5 |
| Nelson, Karin B; Leviton, Alan (2006) Hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med 354:1643-5; author reply 1643-5 |
| Lynch, John Kylan; Han, Christina J; Nee, Linda E et al. (2005) Prothrombotic factors in children with stroke or porencephaly. Pediatrics 116:447-53 |
| Wu, Yvonne W; Lynch, John K; Nelson, Karin B (2005) Perinatal arterial stroke: understanding mechanisms and outcomes. Semin Neurol 25:424-34 |
| Nelson, Karin B (2005) Neonatal encephalopathy: etiology and outcome. Dev Med Child Neurol 47:292 |
| Nelson, Karin B; Dambrosia, James M; Iovannisci, David M et al. (2005) Genetic polymorphisms and cerebral palsy in very preterm infants. Pediatr Res 57:494-9 |
| Nelson, Karin B; Lynch, John K (2004) Stroke in newborn infants. Lancet Neurol 3:150-8 |
| Grether, Judith K; Nelson, Karin B; Walsh, Eileen et al. (2003) Intrauterine exposure to infection and risk of cerebral palsy in very preterm infants. Arch Pediatr Adolesc Med 157:26-32 |
| Nelson, Karin B (2003) Can we prevent cerebral palsy? N Engl J Med 349:1765-9 |
| Lynch, John Kylan; Hirtz, Deborah G; DeVeber, Gabrielle et al. (2002) Report of the National Institute of Neurological Disorders and Stroke workshop on perinatal and childhood stroke. Pediatrics 109:116-23 |
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