Abstract

Progress on this multi-institutional collaborative effort has focused primarily on quantitative morphometric analysis in the brains of behaviorally characterized subjects in relation to estrogen status. In a study of this sort, Hara and colleagues tested whether the synaptic morphology of terminals innervating the dendrites of neurons in Area 46 of the prefrontal cortex are altered in relation to ovarian hormone status and the cognitive outcome of aging. Quantification of ultrastructure examined by electron microscopy focused on non-, single-, and multi-synaptic boutons. The overall pattern of results was that, whereas aging alone had relatively little effect, menopause was reliably linked to synaptic morphology and these effects were coupled with individual differences in cognitive capacities supported by the dorsolateral prefrontal cortex. We anticipate project efforts will continue to illuminate a number of significant womens health issues concerning the modulatory influence of ovarian hormones on normal cognitive aging.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000351-08
Application #
9351945
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Aging
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Crimins, Johanna L; Wang, Athena Ching-Jung; Yuk, Frank et al. (2017) Diverse Synaptic Distributions of G Protein-coupled Estrogen Receptor 1 in Monkey Prefrontal Cortex with Aging and Menopause. Cereb Cortex 27:2022-2033
Snyder, Heather M; Asthana, Sanjay; Bain, Lisa et al. (2016) Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative. Alzheimers Dement 12:1186-1196
Hara, Yuko; Yuk, Frank; Puri, Rishi et al. (2016) Estrogen Restores Multisynaptic Boutons in the Dorsolateral Prefrontal Cortex while Promoting Working Memory in Aged Rhesus Monkeys. J Neurosci 36:901-10
Naugle, Michelle M; Nguyen, Long T; Merceron, Tyler K et al. (2014) G-protein coupled estrogen receptor, estrogen receptor ?, and progesterone receptor immunohistochemistry in the hypothalamus of aging female rhesus macaques given long-term estradiol treatment. J Exp Zool A Ecol Genet Physiol 321:399-414
Young, M E; Ohm, D T; Dumitriu, D et al. (2014) Differential effects of aging on dendritic spines in visual cortex and prefrontal cortex of the rhesus monkey. Neuroscience 274:33-43
Hara, Yuko; Yuk, Frank; Puri, Rishi et al. (2014) Presynaptic mitochondrial morphology in monkey prefrontal cortex correlates with working memory and is improved with estrogen treatment. Proc Natl Acad Sci U S A 111:486-91
Baxter, Mark G; Roberts, Mary T; Gee, Nancy A et al. (2013) Multiple clinically relevant hormone therapy regimens fail to improve cognitive function in aged ovariectomized rhesus monkeys. Neurobiol Aging 34:1882-90
Ohm, Daniel T; Bloss, Erik B; Janssen, William G et al. (2012) Clinically relevant hormone treatments fail to induce spinogenesis in prefrontal cortex of aged female rhesus monkeys. J Neurosci 32:11700-5
Hara, Yuko; Rapp, Peter R; Morrison, John H (2012) Neuronal and morphological bases of cognitive decline in aged rhesus monkeys. Age (Dordr) 34:1051-73
Dumitriu, Dani; Rapp, Peter R; McEwen, Bruce S et al. (2010) Estrogen and the aging brain: an elixir for the weary cortical network. Ann N Y Acad Sci 1204:104-12

Showing the most recent 10 out of 12 publications