Previously we developed conditions for EC cell differentiation to neuronal precusor cells. We identified genes that changed expression during retinoic acid-induced differentiation to neuronal precursor cells. Progress: We found that ACF and Mi2 could have opposing effects on transcription-factor directed chromatin remodeling. We found that Snf2H could both activate and repress transcription. Future: We are interested in determining whether these remodeling enzymes are using different mechanisms.
| Ishii, Haruhiko; Du, Hansen; Zhang, Zhaoqing et al. (2009) Mi2beta shows chromatin enzyme specificity by erasing a DNase I-hypersensitive site established by ACF. J Biol Chem 284:7533-41 |
| Xie, Yi; Kole, Sutapa; Precht, Patricia et al. (2009) S-glutathionylation impairs signal transducer and activator of transcription 3 activation and signaling. Endocrinology 150:1122-31 |
| Du, Hansen; Ishii, Haruhiko; Pazin, Michael J et al. (2008) Activation of 12/23-RSS-dependent RAG cleavage by hSWI/SNF complex in the absence of transcription. Mol Cell 31:641-9 |
