Decline in the immune system is a feature of human aging. Reduction in naive T cell repertoire to combat novel pathogens stems from decreased function of the thymus where T cells develop. Stage-specific signal transduction and gene expression, resulting from reciprocal cell-cell interactions and locally produced cytokines and hormones, is critical for T cell development. Cues from stromal cells regulate an exquisite balance of proliferation, quiescence, cell-death and cell-fate decisions in developing thymocytes. In turn, thymocytes regulate the maturation of thymic epithelial cells. Understanding this interplay at a molecular level will provide insights that might be translated into novel therapies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAG000768-11
Application #
8931591
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Aging
Department
Type
DUNS #
City
State
Country
Zip Code
Pyaram, Kalyani; Sen, Jyoti Misra; Chang, Cheong-Hee (2017) Temporal regulation of Wnt/?-catenin signaling is important for invariant NKT cell development and terminal maturation. Mol Immunol 85:47-56
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Ait-Ali, Djida; Stroth, Nikolas; Sen, Jyoti M et al. (2010) PACAP-cytokine interactions govern adrenal neuropeptide biosynthesis after systemic administration of LPS. Neuropharmacology 58:208-14
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Xu, Mai; Sharma, Archna; Wiest, David L et al. (2009) Pre-TCR-induced beta-catenin facilitates traversal through beta-selection. J Immunol 182:751-8
Xu, Mai; Sharma, Archna; Hossain, M Zulfiquer et al. (2009) Sustained expression of pre-TCR induced beta-catenin in post-beta-selection thymocytes blocks T cell development. J Immunol 182:759-65

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