InCHIANTI is being performed in two sites: Greve in Chianti (Site 1;11,709 inhabitants;19.3% >65 years;located in the middle of a rural area) and Bagno a Ripoli (Village of Antella, site 2, 4704 inhabitants;20.3% >65 years;located immediately adjacent to the urban area of Florence). To obtain two representative samples of the population, the same two stage sampling procedure was used in each of the two sites. For the baseline cohort, in August 1998, a random sample of 1270 persons aged 65 years or older was randomly selected from the population registry of the two sites. Another 29 subjects were randomly selected among those who were 90 years old or older, until at least 30 men and 30 women from this age group were included in the sample. Finally, men and women randomly sampled from the age strata 20-29, 30-39, 40-49, 50-59, and 60-64 years were sequentially invited to participate in the study, until at least 30 men and 30 women for each decade from 20 to 59, and 15 men and 15 women aged 60 to 64 had been enrolled. The InChianti Study cohorts were assessed at baseline in 1998-2000, 3 years later, in 2001-2003, 6 years later, in 2004-2006, and 9 years later, in 2007-2009. As at the three- and six-year follow-ups, the nine-year follow-ups repeated most elements of the baseline evaluation. As at the baseline there were three contacts with participants, once in their homes and on two subsequent occasions in the clinic. Subjects who refused the interview were contacted several more times, one month apart, before being considered definitive refusals. Interviews were conducted at the participants'homes by experienced interviewers. In persons who score 18 or less on the Mini Mental State Examination the interview was administered to a proxy.

National Institute of Health (NIH)
National Institute on Aging (NIA)
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Vespasiani-Gentilucci, Umberto; De Vincentis, Antonio; Ferrucci, Luigi et al. (2018) Low Alanine Aminotransferase Levels in the Elderly Population: Frailty, Disability, Sarcopenia, and Reduced Survival. J Gerontol A Biol Sci Med Sci 73:925-930
Martinez-Gomez, David; Bandinelli, Stefania; Del-Panta, Vieri et al. (2018) Three-Year Changes in Physical Activity and Subsequent Loss of Ability to Walk 400 m in Older Adults: The InCHIANTI Study. Am J Phys Med Rehabil 97:212-215
Ferrucci, Luigi; Fabbri, Elisa (2018) Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol 15:505-522
Corsonello, Andrea; Pedone, Claudio; Bandinelli, Stefania et al. (2018) Predicting survival of older community-dwelling individuals according to five estimated glomerular filtration rate equations: The InChianti study. Geriatr Gerontol Int 18:607-614
Ceresini, Graziano; Marina, Michela; Lauretani, Fulvio et al. (2018) Physical performance across the thyroid function values within the normal range in adult and older persons. Aging Clin Exp Res :
Chen-Edinboro, Lenis P; Murray-Kolb, Laura E; Simonsick, Eleanor M et al. (2018) Association Between Non-Iron-Deficient Anemia and Insomnia Symptoms in Community-Dwelling Older Adults: The Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci 73:380-385
Stenholm, Sari; Ferrucci, Luigi; Vahtera, Jussi et al. (2018) Natural Course of Frailty Components in People Who Develop Frailty Syndrome: Evidence From Two Cohort Studies. J Gerontol A Biol Sci Med Sci :
Martinez-Gomez, David; Bandinelli, Stefania; Del-Panta, Vieri et al. (2017) Three-Year Changes in Physical Activity and Decline in Physical Performance Over 9 Years of Follow-Up in Older Adults: The Invecchiare in Chianti Study. J Am Geriatr Soc 65:1176-1182
Jin, Yichen; Tanaka, Toshiko; Bandinelli, Stefania et al. (2017) Overall Cardiovascular Health Is Associated With All-Cause and Cardiovascular Disease Mortality Among Older Community-Dwelling Men and Women. J Aging Health 29:437-453
Ticinesi, Andrea; Lauretani, Fulvio; Ceda, Gian Paolo et al. (2017) Uric acid and endothelial function in elderly community-dwelling subjects. Exp Gerontol 89:57-63

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