Abstract

Our research project focuses on human malaria infections, therapeutic responses to antimalarial drugs, and why different strains of malaria parasites vary in their infectivities to humans and other primates. In these areas of research, we seek advances that can improve the knowledge of disease processes in malaria and thereby support the discovery and evaluation new antimalarial chemotherapies, diagnostic methods, and vaccines. The research activities in our program are multidisciplinary and include field studies in malaria-endemic regions as well as programs of basic laboratory investigation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI000483-32
Application #
9563832
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
32
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Figan, Christine E; Sá, Juliana M; Mu, Jianbing et al. (2018) A set of microsatellite markers to differentiate Plasmodium falciparum progeny of four genetic crosses. Malar J 17:60
Breglio, Kimberly F; Rahman, Rifat S; Sá, Juliana M et al. (2018) Kelch Mutations in Plasmodium falciparum Protein K13 Do Not Modulate Dormancy after Artemisinin Exposure and Sorbitol Selection In Vitro. Antimicrob Agents Chemother 62:
Obaldia 3rd, Nicanor; Meibalan, Elamaran; Sa, Juliana M et al. (2018) Bone Marrow Is a Major Parasite Reservoir in Plasmodium vivax Infection. MBio 9:
Armistead, Jennifer S; Moraes Barros, Roberto R; Gibson, Tyler J et al. (2018) Infection of mosquitoes from in vitro cultivated Plasmodium knowlesi H strain. Int J Parasitol 48:601-610
Deng, Changsheng; Huang, Bo; Wang, Qi et al. (2018) Large-scale Artemisinin-Piperaquine Mass Drug Administration With or Without Primaquine Dramatically Reduces Malaria in a Highly Endemic Region of Africa. Clin Infect Dis :
Lane, Kristin D; Mu, Jianbing; Lu, Jinghua et al. (2018) Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors. Proc Natl Acad Sci U S A 115:6285-6290
Mu, Jianbing; Andersen, John F; Valenzuela, Jesus G et al. (2017) High-Sensitivity Assays for Plasmodium falciparum Infection by Immuno-Polymerase Chain Reaction Detection of PfIDEh and PfLDH Antigens. J Infect Dis 216:713-722
Moraes Barros, Roberto R; Gibson, Tyler J; Kite, Whitney A et al. (2017) Comparison of two methods for transformation of Plasmodium knowlesi: Direct schizont electroporation and spontaneous plasmid uptake from plasmid-loaded red blood cells. Mol Biochem Parasitol 218:16-22
Kite, Whitney A; Melendez-Muniz, Viviana A; Moraes Barros, Roberto R et al. (2016) Alternative methods for the Plasmodium falciparum artemisinin ring-stage survival assay with increased simplicity and parasite stage-specificity. Malar J 15:94
Miles, Alistair; Iqbal, Zamin; Vauterin, Paul et al. (2016) Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum. Genome Res 26:1288-99

Showing the most recent 10 out of 42 publications