HIV/SIV Replication In Vivo

Koup, Richard A.

Abstract

HIV is known to replicate primarily in activated CD4+ T cells. In addition, HIV can remain silent in unactivated T cells - what is referred to as the latent reservoir. Because current anti-retroviral agents only target actively replicating virus, the existance of a latent reservoir is the primary reason why current strategies do not eliminate HIV from people. This study seeks to define the subsets of CD4+ T cells in patients that contain HIV - in both active and latent forms - as a basis to develop strategies to eliminate HIV from the body. In addition, the project seeks to study ways in which to limit SHIV replication in non-human primates as a model system for studying HIV replication in humans.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIAAI005014-18
• Application #: 10019250
• Support Year: 18
• Fiscal Year: 2019

Institution

• Name: National Institute of Allergy and Infectious Diseases

Publications

Gama, Lucio; Koup, Richard A (2018) New-Generation High-Potency and Designer Antibodies: Role in HIV-1 Treatment. Annu Rev Med 69:409-419

Gay, Cynthia L; Bosch, Ronald J; Ritz, Justin et al. (2017) Clinical Trial of the Anti-PD-L1 Antibody BMS-936559 in HIV-1 Infected Participants on Suppressive Antiretroviral Therapy. J Infect Dis 215:1725-1733

Paris, Robert M; Milagres, Lucimar G; Moysi, Eirini et al. (2017) Lower Baseline Germinal Center Activity and Preserved Th1 Immunity Are Associated With Hepatitis B Vaccine Response in Treated HIV Infection. Pathog Immun 2:66-88

Margolis, David M; Koup, Richard A; Ferrari, Guido (2017) HIV antibodies for treatment of HIV infection. Immunol Rev 275:313-323

Nishimura, Yoshiaki; Gautam, Rajeev; Chun, Tae-Wook et al. (2017) Early antibody therapy can induce long-lasting immunity to SHIV. Nature 543:559-563

Julg, Boris; Pegu, Amarendra; Abbink, Peter et al. (2017) Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys. J Virol 91:

Saharia, Kapil K; Petrovas, Constantinos; Ferrando-Martinez, Sara et al. (2016) Tuberculosis Therapy Modifies the Cytokine Profile, Maturation State, and Expression of Inhibitory Molecules on Mycobacterium tuberculosis-Specific CD4+ T-Cells. PLoS One 11:e0158262

Bolton, Diane L; Pegu, Amarendra; Wang, Keyun et al. (2016) Human Immunodeficiency Virus Type 1 Monoclonal Antibodies Suppress Acute Simian-Human Immunodeficiency Virus Viremia and Limit Seeding of Cell-Associated Viral Reservoirs. J Virol 90:1321-32

Boritz, Eli A; Darko, Samuel; Swaszek, Luke et al. (2016) Multiple Origins of Virus Persistence during Natural Control of HIV Infection. Cell 166:1004-1015

Francica, Joseph R; Sheng, Zizhang; Zhang, Zhenhai et al. (2015) Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization. Nat Commun 6:6565