HIV is known to replicate primarily in activated CD4+ T cells. In addition, HIV can remain silent in unactivated T cells - what is referred to as the latent reservoir. Because current anti-retroviral agents only target actively replicating virus, the existance of a latent reservoir is the primary reason why current strategies do not eliminate HIV from people. This study seeks to define the subsets of CD4+ T cells in patients that contain HIV - in both active and latent forms - as a basis to develop strategies to eliminate HIV from the body. In addition, the project seeks to study ways in which to limit SHIV replication in non-human primates as a model system for studying HIV replication in humans.

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Project End
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Budget End
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18
Fiscal Year
2019
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Indirect Cost
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