Abstract

We perform in depth analyses of the immune response to multiple different vaccines and to multiple different natural viral infections in order to dissect those immune responses that mediate protection from viral infection or dissemination. Antigen presenting cells are tracked from the time of vaccination to determine where and how they present antigen, and in what context, to B and T cells in the lymph nodes. The effects of chronic immune activation and antigen stimulation on the immune response to different pathogens are studied. In addition, the effects of HIV infection on different pathogen-specific T cell responses are evaluated.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAAI005073-13
Application #
9339100
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
13
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
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State
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  Publications

Xu, Ling; Pegu, Amarendra; Rao, Ercole et al. (2017) Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques. Science 358:85-90
Ferrando-Martinez, Sara; De Pablo-Bernal, Rebeca S; De Luna-Romero, Marta et al. (2017) Thymic Function Failure Is Associated With Human Immunodeficiency Virus Disease Progression. Clin Infect Dis 64:1191-1197
Ewer, Katie; Rampling, Tommy; Venkatraman, Navin et al. (2016) A Monovalent Chimpanzee Adenovirus Ebola Vaccine Boosted with MVA. N Engl J Med 374:1635-46
Liang, Frank; Ploquin, Aurélie; Hernández, José DelaO et al. (2015) Dissociation of skeletal muscle for flow cytometric characterization of immune cells in macaques. J Immunol Methods 425:69-78
Sarwar, Uzma N; Costner, Pamela; Enama, Mary E et al. (2015) Safety and immunogenicity of DNA vaccines encoding Ebolavirus and Marburgvirus wild-type glycoproteins in a phase I clinical trial. J Infect Dis 211:549-57
Ledgerwood, Julie E; Coates, Emily E; Yamshchikov, Galina et al. (2015) Safety, Pharmacokinetics, and Neutralization of the Broadly Neutralizing HIV-1 Human Monoclonal Antibody VRC01 in Healthy Adults. Clin Exp Immunol :
Francica, Joseph R; Sheng, Zizhang; Zhang, Zhenhai et al. (2015) Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization. Nat Commun 6:6565
Ledgerwood, Julie E; Hu, Zonghui; Costner, Pamela et al. (2015) Phase I clinical evaluation of seasonal influenza hemagglutinin (HA) DNA vaccine prime followed by trivalent influenza inactivated vaccine (IIV3) boost. Contemp Clin Trials 44:112-118
Williams, Wilton B; Liao, Hua-Xin; Moody, M Anthony et al. (2015) HIV-1 VACCINES. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota cross-reactive antibodies. Science 349:aab1253
Kibuuka, Hannah; Berkowitz, Nina M; Millard, Monica et al. (2015) Safety and immunogenicity of Ebola virus and Marburg virus glycoprotein DNA vaccines assessed separately and concomitantly in healthy Ugandan adults: a phase 1b, randomised, double-blind, placebo-controlled clinical trial. Lancet 385:1545-54

Showing the most recent 10 out of 71 publications