We have mapped a unique histone variant genome wide in colorectal cancer cell lines and found that it is clustered tightly at epigenetically distinctive regions. We have mapped these regions further using cytological methods and found a subset that enriched in regions implicated in tumor biology. Future goals involve mapping histone variants in tumors in order to track progression of aberrant chromatin structures as a consequence of the tumorigenic process, and discovering remodelers and processes involved in the mis-localization.
| Nye, Jonathan; Melters, Daniël P; Dalal, Yamini (2018) The Art of War: harnessing the epigenome against cancer. F1000Res 7:141 |
| Nuccio, A G; Bui, M; Dalal, Y et al. (2017) Mass Spectrometry-Based Methodology for Identification of Native Histone Variant Modifications From Mammalian Tissues and Solid Tumors. Methods Enzymol 586:275-290 |
| Melters, Daniël P; Nye, Jonathan; Zhao, Haiqing et al. (2015) Chromatin Dynamics in Vivo: A Game of Musical Chairs. Genes (Basel) 6:751-76 |
| Quénet, Delphine; Dalal, Yamini (2012) The CENP-A nucleosome: a dynamic structure and role at the centromere. Chromosome Res 20:465-79 |
