Abstract

This project was begun on August 2, 2009. There is currently not adequate data acquired in the past month to be able to provide a comprehensive Project Summary Statement. Nevertheless, we have currently data identifying sirtuins and potential interacting proteins in the central nervous system. We also have sirtuin 2 knockout and wild-type mice which have been re-derived and will be utilized in cerebral irradiation experiments, and will be used as a model of radiation-induced neurocognitive changes and neuronal degeneration.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIABC011222-01
Application #
7966244
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2009
Total Cost
$144,122
Indirect Cost

  Institution

Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Smart, DeeDee (2017) Radiation Toxicity in the Central Nervous System: Mechanisms and Strategies for Injury Reduction. Semin Radiat Oncol 27:332-339
Shukla, Sudhanshu; Shankavaram, Uma T; Nguyen, Phuongmai et al. (2015) Radiation-Induced Alteration of the Brain Proteome: Understanding the Role of the Sirtuin 2 Deacetylase in a Murine Model. J Proteome Res 14:4104-17
Nguyen, Phuongmai; Lee, Sunmin; Lorang-Leins, Dominique et al. (2014) SIRT2 interacts with ?-catenin to inhibit Wnt signaling output in response to radiation-induced stress. Mol Cancer Res 12:1244-53