Ongoing and planned studies include evaluation of populations exposed to benzene, chlorinated solvents, organochlorines, disinfection byproducts. polycyclic aromatic hydrocarbons, arsenic, formaldehyde, diesel exhaust, coal combustion products, and selected pesticides. On-going case-control studies include stomach, esophagus, brain, bladder, renal cell, thyroid, prostate and breast cancer. The study of NHL and other hematological malignancies is a particularly important area of focus. NHL is one of the most common malignancies occurring among immunosuppressed individuals, including those with HIV/AIDS and those receiving iatrogenic immunosuppression to prevent graft rejection following transplantation. We are conducting a large case-control study of NHL, a large cohort study of populations exposed to agricultural agents including those that increase risk of NHL, and cohort and molecular epidemiology studies of populations exposed to chemicals that have been associated with increased risk of NHL including benzene and trichloroethylene. These studies will examine the role of genetic, occupational, environmental, and lifestyle risk factors, as well as viral exposures including HIV, and analyze interactions between them to provide further insight into the pathogenesis of NHL.

National Institute of Health (NIH)
National Cancer Institute (NCI)
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Wong, Jason Y Y; Margolis, Helene G; Machiela, Mitchell et al. (2018) Outdoor air pollution and mosaic loss of chromosome Y in older men from the Cardiovascular Health Study. Environ Int 116:239-247
Grigoryan, Hasmik; Edmands, William M B; Lan, Qing et al. (2018) Adductomic signatures of benzene exposure provide insights into cancer induction. Carcinogenesis 39:661-668
Rothman, Nathaniel; Zhang, Luoping; Smith, Martyn T et al. (2018) Formaldehyde, Hematotoxicity, and Chromosomal Changes-Response. Cancer Epidemiol Biomarkers Prev 27:120-121
Seow, Wei Jie; Matsuo, Keitaro; Hsiung, Chao Agnes et al. (2017) Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. Hum Mol Genet 26:454-465
Wong, Jason Y Y; Hu, Wei; Downward, George S et al. (2017) Personal exposure to fine particulate matter and benzo[a]pyrene from indoor air pollution and leukocyte mitochondrial DNA copy number in rural China. Carcinogenesis 38:893-899
GBD 2015 Healthcare Access and Quality Collaborators. Electronic address:; GBD 2015 Healthcare Access and Quality Collaborators (2017) Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the Global Burden of Disease Study 2015. Lancet 390:231-266
Rothman, Nathaniel; Lan, Qing; Smith, Martyn T et al. (2017) Response to letter to the editor of Carcinogenesis by Pira et al., 2017. Carcinogenesis 38:1253-1255
Wong, Jason Y; Bassig, Bryan A; Vermeulen, Roel et al. (2017) Sleep Duration across the Adult Lifecourse and Risk of Lung Cancer Mortality: A Cohort Study in Xuanwei, China. Cancer Prev Res (Phila) 10:327-336
Lu, Sixin S; Grigoryan, Hasmik; Edmands, William M B et al. (2017) Profiling the Serum Albumin Cys34 Adductome of Solid Fuel Users in Xuanwei and Fuyuan, China. Environ Sci Technol 51:46-57
Seow, Wei Jie; Lan, Qing (2016) Domestic incense use and lung cancer in Asia: a review. Rev Environ Health 31:155-8

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