Ongoing and planned studies include evaluation of populations exposed to benzene, chlorinated solvents, organochlorines, disinfection byproducts. polycyclic aromatic hydrocarbons, arsenic, formaldehyde, diesel exhaust, coal combustion products, and selected pesticides. On-going case-control studies include stomach, esophagus, brain, bladder, renal cell, thyroid, prostate and breast cancer. The study of NHL and other hematological malignancies is a particularly important area of focus. NHL is one of the most common malignancies occurring among immunosuppressed individuals, including those with HIV/AIDS and those receiving iatrogenic immunosuppression to prevent graft rejection following transplantation. We are conducting a large case-control study of NHL, a large cohort study of populations exposed to agricultural agents including those that increase risk of NHL, and cohort and molecular epidemiology studies of populations exposed to chemicals that have been associated with increased risk of NHL including benzene and trichloroethylene. These studies will examine the role of genetic, occupational, environmental, and lifestyle risk factors, as well as viral exposures including HIV, and analyze interactions between them to provide further insight into the pathogenesis of NHL.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010121-24
Application #
10007400
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
24
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
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