Traditionally, occupational research has focused primarily on white men, even though women comprise nearly half of the U.S. civilian workforce, and minorities are often employed in jobs with hazardous exposures. The OEEB has undertaken a number of population-based epidemiologic studies which include women and minorities during the past year, with a substantial focus in occupation . In the Agricultural Health Study, a prospective cohort study of more than 90,000 subjects, including approximately 32,000 women and 2,000 minorities, both direct occupational exposure and indirect environmental exposure to pesticides and other exposures are being evaluated for association with breast, ovarian, thyroid and other cancers. Diesel exhaust from farm equipment has also been evaluated for associations with lung cancer among the spouses of farmers. In addition, living near concentrated animal feeding operations (CAFOs) are being evaluated for associations with several cancer types, including lung and other respiratory cancers. The Shanghai Women's Study is a prospective cohort study of 75,000 women conducted by Vanderbilt University in collaboration with NCI and the Shanghai Cancer Institute. Blood/buccal cell and urine samples have been collected from nearly 90% of participants. Exposure assessment to benzene has been based on industrial monitoring data maintained by the Shanghai municipal government and is being evaluated for associations with leukemia and lymphoma. Cancer risk in relation to occupation and industry of employment is being evaluated, including a recent report of lung cancer risk associated with employment in certain occupations that may have exposure to potential industrial carcinogens. Two studies have also been conducted within this study, focused on the effect of night shift work on melatonin levels and on overall cancer risk. The New England Bladder Cancer study, a large multicenter case-control study of bladder cancer is on-going to examine environmental and occupational risk factors and the reasons for the consistently elevated incidence and mortality of this cancer in New England and includes the largest number of women of any previous case-control study. The U.S. kidney cancer study is the first study of this cancer that included a sufficient number of African Americans for separate evaluation of their risks, and the contribution of environmental and occupational risk factors to the racial disparity in incidence of this cancer. NCI is leading the environmental sampling component of the California childhood leukemia case-control study. The approximately 40% Hispanic and 10% Asian participants in this study provide an opportunity to evaluate agricultural and other risk factors among these minorities. In the Iowa Women's Health Study, environmental contaminants in drinking water are being evaluated for associations with cancers of the bladder, ovary, pancreas and colon.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010123-23
Application #
9770245
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
23
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Bassig, Bryan A; Willhauck-Fleckenstein, Martina; Shu, Xiao-Ou et al. (2018) Serologic markers of viral infection and risk of non-Hodgkin lymphoma: A pooled study of three prospective cohorts in China and Singapore. Int J Cancer 143:570-579
Koutros, Stella; Baris, Dalsu; Waddell, Richard et al. (2018) Potential effect modifiers of the arsenic-bladder cancer risk relationship. Int J Cancer 143:2640-2646
Schinasi, Leah H; Brown, Elizabeth E; Camp, Nicola J et al. (2016) Multiple myeloma and family history of lymphohaematopoietic cancers: Results from the International Multiple Myeloma Consortium. Br J Haematol 175:87-101
Kim, Christopher; Seow, Wei Jie; Shu, Xiao-Ou et al. (2016) Cooking Coal Use and All-Cause and Cause-Specific Mortality in a Prospective Cohort Study of Women in Shanghai, China. Environ Health Perspect 124:1384-9
Costas, Laura; Lambert, Brice H; Birmann, Brenda M et al. (2016) A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium. Cancer Epidemiol Biomarkers Prev 25:217-21
Kim, Christopher; Gao, Yu-Tang; Xiang, Yong-Bing et al. (2015) Home kitchen ventilation, cooking fuels, and lung cancer risk in a prospective cohort of never smoking women in Shanghai, China. Int J Cancer 136:632-8
Wu, Sheng Hui; Shu, Xiao Ou; Milne, Ginger et al. (2015) Uric acid correlates to oxidation and inflammation in opposite directions in women. Biomarkers 20:225-31
Hohenadel, Karin; Raj, Priyanka; Demers, Paul A et al. (2015) The inclusion of women in studies of occupational cancer: a review of the epidemiologic literature from 1991-2009. Am J Ind Med 58:276-81
Engel, Lawrence S; Buckley, Jessie P; Yang, Gong et al. (2014) Predictors and variability of repeat measurements of urinary phenols and parabens in a cohort of Shanghai women and men. Environ Health Perspect 122:733-40
Seow, Wei Jie; Cawthon, Richard M; Purdue, Mark P et al. (2014) Telomere length in white blood cell DNA and lung cancer: a pooled analysis of three prospective cohorts. Cancer Res 74:4090-8

Showing the most recent 10 out of 60 publications