SUCCEED directed by Dr. Wentzensen is a cross-sectional study among women referred for abnormal cevrical cancer screening results focused on the identification of biomarkers of risk at each progressive disease stage, aimed to identify the molecular events that are necessary and sufficient for progression to cervical cancer. Frozen specimens, often multiple, from 2,500 women with varying grades of cervical neoplasia (including the ectocervix, transformation zone, and endocervix) have already been collected. In a new study, the Biopsy Study conducted at the same center in Oklahoma, Dr. Wentzensen is investigating the earliest discernible transitions from HPV infection to CIN3 and the best methods for colposcopic detection of CIN3 to improve current cervical cancer prevention strategies. The ALTS clinical trial evaluated management options for women with abnormal cervical cancer screening results and has been completed several years ago. The specimens collected in women with minor cytological abnormalities and 2 year follow up still serve as an important resource to evaluate HPV tests and novel biomarkers, such as viral methylation. The Anal Cancer Screening Study in HIV positive men who have sex with men is conducted with Kaiser Permanente Northern California to identify the HPV genotype attribution in anal precancer and to study biomarkers for anal cancer screening The Intramural to India project is a new effort to study cervical cancer precursors among HIV-infected women in India. The case control study of invasive cervical cancer in four Latin-American countries is an important resource to study sero-epidemiologic markers of cervical cancer risk.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Division of Cancer Epidemiology and Genetics
Zip Code
Wentzensen, N; Litwin, T (2018) Accuracy of visual cervical screening: verification bias revisited. BJOG 125:554
Clarke, Megan A; Wentzensen, Nicolas (2018) Strategies for screening and early detection of anal cancers: A narrative and systematic review and meta-analysis of cytology, HPV testing, and other biomarkers. Cancer Cytopathol :
Cuschieri, Kate; Ronco, Guglielmo; Lorincz, Attila et al. (2018) Eurogin roadmap 2017: Triage strategies for the management of HPV-positive women in cervical screening programs. Int J Cancer 143:735-745
Litwin, Tamara R; Clarke, Megan A; Dean, Michael et al. (2017) Somatic Host Cell Alterations in HPV Carcinogenesis. Viruses 9:
Wentzensen, Nicolas; Arbyn, Marc; Berkhof, Johannes et al. (2017) Eurogin 2016 Roadmap: how HPV knowledge is changing screening practice. Int J Cancer 140:2192-2200
Wentzensen, N (2017) Optimising cervical cancer screening programs: how to evaluate incremental changes? BJOG 124:485
Clarke, Megan A; Luhn, Patricia; Gage, Julia C et al. (2017) Discovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer. Int J Cancer 141:701-710
Waxman, Alan G; Conageski, Christine; Silver, Michelle I et al. (2017) ASCCP Colposcopy Standards: How Do We Perform Colposcopy? Implications for Establishing Standards. J Low Genit Tract Dis 21:235-241
Schiffman, Mark (2017) Cervical cancer screening: Epidemiology as the necessary but not sufficient basis of public health practice. Prev Med 98:3-4
Wentzensen, Nicolas; Arbyn, Marc (2017) HPV-based cervical cancer screening- facts, fiction, and misperceptions. Prev Med 98:33-35

Showing the most recent 10 out of 139 publications