Abstract

Infection, immune disturbances, and inflammation overlap in the ways that they damage tissues and promote development of cancer. Major studies under this project include the HIV/AIDS Cancer Match Study and Transplant Cancer Match Study, which link population-based registries of HIV infected people and transplant recipients to cancer registries in the U.S. Additional studies characterize risk factors for specific cancers in HIV-infected people and transplant recipients. Risk of non-Hodgkin lymphoma and lung cancer is elevated in immunosuppressed populations, and these two malignancies are an important focus of study. Other cancers of interest, because they are associated with HIV or organ transplant, include Kaposi sarcoma, liver cancer, cancers related to human papillomavirus (such as cervical cancer and anal cancer), Hodgkin lymphoma, melanoma, non-melanoma skin cancers, kidney cancer, and multiple myeloma. Some studies under this project address the role of HIV, other chronic infections, immune disturbance, and inflammation in these and other cancers. Other studies, which focus on cancer risk in the elderly related to immune and other conditions, involve analyses of linked SEER-Medicare registry data.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010150-16
Application #
9154193
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
16
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Mahale, Parag; Engels, Eric A; Coghill, Anna E et al. (2018) Cancer Risk in Older Persons Living With Human Immunodeficiency Virus Infection in the United States. Clin Infect Dis 67:50-57
Shiels, Meredith S; Freedman, Neal D; Thomas, David et al. (2018) Trends in U.S. Drug Overdose Deaths in Non-Hispanic Black, Hispanic, and Non-Hispanic White Persons, 2000-2015. Ann Intern Med 168:453-455
Altekruse, Sean F; Shiels, Meredith S; Modur, Sharada P et al. (2018) Cancer burden attributable to cigarette smoking among HIV-infected people in North America. AIDS 32:513-521
Mahale, Parag; Shiels, Meredith S; Lynch, Charles F et al. (2018) Incidence and outcomes of primary central nervous system lymphoma in solid organ transplant recipients. Am J Transplant 18:453-461
Gupta, Gaurav; Kuppachi, Sarat; Kalil, Roberto S et al. (2018) Treatment for presumed BK polyomavirus nephropathy and risk of urinary tract cancers among kidney transplant recipients in the United States. Am J Transplant 18:245-252
Shiels, Meredith S; Islam, Jessica Y; Rosenberg, Philip S et al. (2018) Projected Cancer Incidence Rates and Burden of Incident Cancer Cases in HIV-Infected Adults in the United States Through 2030. Ann Intern Med 168:866-873
Shiels, Meredith S; Kirk, Gregory D; Drummond, M Bradley et al. (2018) HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D. J Infect Dis 217:413-417
Colón-López, Vivian; Shiels, Meredith S; Machin, Mark et al. (2018) Anal Cancer Risk Among People With HIV Infection in the United States. J Clin Oncol 36:68-75
Ferreira, Mariana P; Coghill, Anna E; Chaves, Claudia B et al. (2017) Outcomes of cervical cancer among HIV-infected and HIV-uninfected women treated at the Brazilian National Institute of Cancer. AIDS 31:523-531
Fink, Aliza K; Yanik, Elizabeth L; Marshall, Bruce C et al. (2017) Cancer risk among lung transplant recipients with cystic fibrosis. J Cyst Fibros 16:91-97

Showing the most recent 10 out of 155 publications