Non-Hodgkin lymphoma (NHL) is the sixth most common malignancy in the US. By improving understanding of the causes of NHL in the general population, we will identify the individuals at highest risk of developing NHL as well as elucidate mechanisms of lymphomagenesis. Additionally, NHL is one of the most common malignancies occurring among immunosuppressed individuals, including those with HIV/AIDS and those receiving iatrogenic immunosuppression to prevent graft rejection following transplantation. Because individuals with HIV are living longer with improved immune function, this research will identify HIV-positive individuals who are at highest risk for developing NHL based on other etiologic factors.1. We completed analysis of the main case-control study and published approximately 80 reports in peer-reviewed journals. 2. To conduct a GWAS and to study genetic polymorphisms with more power, we are pooling data within the International Lymphoma Epidemiology Consortium (InterLymph). 3. We continued to collaborate with InterLymph on other analyses as well, including a broad range of environmental, medical history, and lifestyle factors.4. Through this collaborative research, we demonstrated that the patterns of risk vary according to the subtype of lymphoma. In particular, we showed that various immune-related medical conditions (e.g., autoimmune diseases, hepatitis C viral infection) are most closely associated with certain NHL subtypes. These subtypes are the same as those that are most strongly elevated among individuals with HIV/AIDS and following solid organ transplantation. 5. We combined environmental data from other sources with study data to continue to investigate environmental risks. This work is ongoing.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010170-17
Application #
9549616
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code
Kleinstern, Geffen; Camp, Nicola J; Goldin, Lynn R et al. (2018) Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis. Blood 131:2541-2551
Bernatsky, Sasha; Velásquez García, Héctor A; Spinelli, John J et al. (2017) Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. Lupus Sci Med 4:e000187
Deziel, Nicole C; Nuckols, John R; Jones, Rena R et al. (2017) Comparison of industrial emissions and carpet dust concentrations of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans in a multi-center U.S. study. Sci Total Environ 580:1276-1286
Teras, Lauren R; DeSantis, Carol E; Cerhan, James R et al. (2016) 2016 US lymphoid malignancy statistics by World Health Organization subtypes. CA Cancer J Clin :
Linet, Martha S; Brown, Linda M; Mbulaiteye, Sam M et al. (2016) International long-term trends and recent patterns in the incidence of leukemias and lymphomas among children and adolescents ages 0-19 years. Int J Cancer 138:1862-74
Nordsborg, Rikke Baastrup; Sloan, Chantel D; Shahid, Haseeb et al. (2015) Investigation of spatio-temporal cancer clusters using residential histories in a case-control study of non-Hodgkin lymphoma in the United States. Environ Health 14:48
Paltiel, Ora; Tikellis, Gabriella; Linet, Martha et al. (2015) Birthweight and Childhood Cancer: Preliminary Findings from the International Childhood Cancer Cohort Consortium (I4C). Paediatr Perinat Epidemiol 29:335-45
Czarnota, Jenna; Gennings, Chris; Colt, Joanne S et al. (2015) Analysis of Environmental Chemical Mixtures and Non-Hodgkin Lymphoma Risk in the NCI-SEER NHL Study. Environ Health Perspect 123:965-70
DellaValle, Curt T; Purdue, Mark P; Ward, Mary H et al. (2015) Validity of expert assigned retrospective estimates of occupational polychlorinated biphenyl exposure. Ann Occup Hyg 59:609-15
Stenehjem, J S; Kjærheim, K; Bråtveit, M et al. (2015) Benzene exposure and risk of lymphohaematopoietic cancers in 25?000 offshore oil industry workers. Br J Cancer 112:1603-12

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