Abstract

The goals will be achieved by a) evaluating obesity, energy balance, and physcial activity in relation to cancer incidence and survival;b) Improving assessment of energy intake, output, and body phenotype;c) Evaluating biomarkers to determine mechanisms including inflammatory cytokines (CRP, IL-6, TNF-alpha), growth factors and their major binding proteins (IGF-1 and IGFBP-3), steroid hormones (testosterone, estrogen, SHBG) in relation to cancer and intermediate outs comes such as weight loss and weight gain d) evaluate novel such as metabolomics in assessing obesity, energy balance, and physical activity and body phenotype and in relation to cancer risk. Although this project is for all cancer, its particular cancer includes breast, colorectal, and pancreatic cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIACP010197-06
Application #
8565456
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
2012
Total Cost
$451,525
Indirect Cost

  Institution

Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Saint-Maurice, Pedro F; Troiano, Richard P; Matthews, Charles E et al. (2018) Moderate-to-Vigorous Physical Activity and All-Cause Mortality: Do Bouts Matter? J Am Heart Assoc 7:
Saint-Maurice, Pedro F; Troiano, Richard P; Berrigan, David et al. (2018) Volume of Light Versus Moderate-to-Vigorous Physical Activity: Similar Benefits for All-Cause Mortality? J Am Heart Assoc 7:
Moore, Steven C; Playdon, Mary C; Sampson, Joshua N et al. (2018) A Metabolomics Analysis of Body Mass Index and Postmenopausal Breast Cancer Risk. J Natl Cancer Inst 110:588-597
Patel, Alpa V; Maliniak, Maret L; Rees-Punia, Erika et al. (2018) Prolonged Leisure-Time Spent Sitting in Relation to Cause-specific Mortality in a Large U.S. Cohort. Am J Epidemiol :
McNeil, Jessica; Farris, Megan S; Ruan, Yibing et al. (2018) Effects of prescribed aerobic exercise volume on physical activity and sedentary time in postmenopausal women: a randomized controlled trial. Int J Behav Nutr Phys Act 15:27
Derkach, Andriy; Sampson, Joshua; Joseph, Justin et al. (2017) Effects of dietary sodium on metabolites: the Dietary Approaches to Stop Hypertension (DASH)-Sodium Feeding Study. Am J Clin Nutr 106:1131-1141
Keadle, Sarah K; Conroy, David E; Buman, Matthew P et al. (2017) Targeting Reductions in Sitting Time to Increase Physical Activity and Improve Health. Med Sci Sports Exerc 49:1572-1582
Menni, Cristina; Migaud, Marie; Kastenmüller, Gabi et al. (2017) Metabolomic Profiling of Long-Term Weight Change: Role of Oxidative Stress and Urate Levels in Weight Gain. Obesity (Silver Spring) :
Bamia, Christina; Orfanos, Philippos; Juerges, Hendrik et al. (2017) Self-rated health and all-cause and cause-specific mortality of older adults: Individual data meta-analysis of prospective cohort studies in the CHANCES Consortium. Maturitas 103:37-44
Alessa, Hala B; Chomistek, Andrea K; Hankinson, Susan E et al. (2017) Objective Measures of Physical Activity and Cardiometabolic and Endocrine Biomarkers. Med Sci Sports Exerc 49:1817-1825

Showing the most recent 10 out of 49 publications