PPT:The PPT was a randomized, controlled trial being carried out at eight Clinical Centers in the United States. The dietary goals for the intervention arm were 20% of calories from fat, 18g fiber/1000 kcal, and 5-8 servings of fruits and vegetables (the exact number based on caloric intake). Three different dietary assessment instruments were used in the PPT: a modified Block/NCI Food Frequency Questionnaire (FFQ), Four Day Food Records (4DFR), and 24 Hour Recalls. Participants underwent colonoscopy again at baseline and at one (T1) and four (T4) years into the study. Blood specimens were collected on all participants annually. Recruitment went on from 1991-4. A total of 38,277 potential participants were screened at the eight Clinical Centers. Of these, 2079 were randomized into the study, with 1037 in the intervention and 1042 in the control group. The mean age of PPT participants at baseline was 61.5 years. 35% of participants are women, 10% minority. T4 colonoscopic endpoint assessment and active intervention were completed in early April, 1998. A report of the main study findings was published in 2000. years ago (New Engl J Med 2000;342:1149-55). Additional manuscripts have been published, submitted, or are in preparation. The Continued Follow-up Study should has now been completed;a report is now in press.CONCeRN:Asymptomatic women were referred for colorectal screening to one of three regional military medical centers, including Bethesda Naval Hospital, from 1999 to 2002. Blood and tissue samples were collected as well as general health information, along with a detailed risk factor questionnaire. Dietary and biospecimen analyses are currently underway using data from the etiologic component of the study. These include an investigation of meat and meat-mutagens and the risk of colorectal adenoma as well as a study of genomic methylation of leukocyte DNA and colorectal adenoma risk, and modification by dietary folate.

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Vogtmann, Emily; Hua, Xing; Zhou, Liang et al. (2018) Temporal Variability of Oral Microbiota over 10 Months and the Implications for Future Epidemiologic Studies. Cancer Epidemiol Biomarkers Prev 27:594-600
Sinha, Rashmi; Goedert, James J; Vogtmann, Emily et al. (2018) Quantification of Human Microbiome Stability Over 6 Months: Implications for Epidemiologic Studies. Am J Epidemiol 187:1282-1290
Jacobs, Elizabeth T; Gupta, Samir; Baron, John A et al. (2018) Family history of colorectal cancer in first-degree relatives and metachronous colorectal adenoma. Am J Gastroenterol 113:899-905
Sinha, Rashmi; Abu-Ali, Galeb; Vogtmann, Emily et al. (2017) Assessment of variation in microbial community amplicon sequencing by the Microbiome Quality Control (MBQC) project consortium. Nat Biotechnol 35:1077-1086
Vogtmann, Emily; Chen, Jun; Kibriya, Muhammad G et al. (2017) Comparison of Fecal Collection Methods for Microbiota Studies in Bangladesh. Appl Environ Microbiol 83:
Vogtmann, Emily; Chen, Jun; Amir, Amnon et al. (2017) Comparison of Collection Methods for Fecal Samples in Microbiome Studies. Am J Epidemiol 185:115-123
Vogtmann, Emily; Hua, Xing; Zeller, Georg et al. (2016) Colorectal Cancer and the Human Gut Microbiome: Reproducibility with Whole-Genome Shotgun Sequencing. PLoS One 11:e0155362
Sinha, Rashmi; Vogtmann, Emily; Chen, Jun et al. (2016) Fecal Microbiome in Epidemiologic Studies-Response. Cancer Epidemiol Biomarkers Prev 25:870-1
Loftfield, Erikka; Vogtmann, Emily; Sampson, Joshua N et al. (2016) Comparison of Collection Methods for Fecal Samples for Discovery Metabolomics in Epidemiologic Studies. Cancer Epidemiol Biomarkers Prev 25:1483-1490
Sinha, Rashmi; Ahn, Jiyoung; Sampson, Joshua N et al. (2016) Fecal Microbiota, Fecal Metabolome, and Colorectal Cancer Interrelations. PLoS One 11:e0152126

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