Abstract

High rates of relapse to drug use after prolonged drug-free periods characterize the behavior of people addicted to opioid and psychostimulant drugs. The behavioral and neurochemical events that contribute to these high relapse rates, however, are not well understood. Relapse can be induced in human subjects and laboratory animals by re-exposure to the drug previously used or re-exposure to environmental cues paired with drug self-administration. We are using different animal models of relapse to study brain systems and neurotransmitters involved in relapse induced by these stimuli in rats with a history of opioid (heroin, oxycodone) and psychostimulant (cocaine, methamphetamine) self-administration.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADA000434-17
Application #
9339204
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
National Institute on Drug Abuse
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Lê, A D; Funk, Douglas; Coen, Kathleen et al. (2018) Role of ?-Opioid Receptors in the Bed Nucleus of Stria Terminalis in Reinstatement of Alcohol Seeking. Neuropsychopharmacology 43:838-850
Marchant, Nathan J; Campbell, Erin J; Kaganovsky, Konstantin (2018) Punishment of alcohol-reinforced responding in alcohol preferring P rats reveals a bimodal population: Implications for models of compulsive drug seeking. Prog Neuropsychopharmacol Biol Psychiatry 87:68-77
Pelloux, Yann; K Hoots, Jennifer; Cifani, Carlo et al. (2017) Context-induced relapse to cocaine seeking after punishment-imposed abstinence is associated with activation of cortical and subcortical brain regions. Addict Biol :
Caprioli, Daniele; Venniro, Marco; Zhang, Michelle et al. (2017) Role of Dorsomedial Striatum Neuronal Ensembles in Incubation of Methamphetamine Craving after Voluntary Abstinence. J Neurosci 37:1014-1027
Adhikary, Sweta; Caprioli, Daniele; Venniro, Marco et al. (2017) Incubation of extinction responding and cue-induced reinstatement, but not context- or drug priming-induced reinstatement, after withdrawal from methamphetamine. Addict Biol 22:977-990
Solis Jr, Ernesto; Cameron-Burr, Keaton T; Shaham, Yavin et al. (2017) Intravenous Heroin Induces Rapid Brain Hypoxia and Hyperglycemia that Precede Brain Metabolic Response. eNeuro 4:
Sharpe, Melissa J; Marchant, Nathan J; Whitaker, Leslie R et al. (2017) Lateral Hypothalamic GABAergic Neurons Encode Reward Predictions that Are Relayed to the Ventral Tegmental Area to Regulate Learning. Curr Biol 27:2089-2100.e5
Venniro, Marco; Zhang, Michelle; Shaham, Yavin et al. (2017) Incubation of Methamphetamine but not Heroin Craving After Voluntary Abstinence in Male and Female Rats. Neuropsychopharmacology 42:1126-1135
Xue, Yan-Xue; Deng, Jia-Hui; Chen, Ya-Yun et al. (2017) Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving. JAMA Psychiatry 74:224-232
Fredriksson, Ida; Adhikary, Sweta; Steensland, Pia et al. (2017) Prior Exposure to Alcohol Has No Effect on Cocaine Self-Administration and Relapse in Rats: Evidence from a Rat Model that Does Not Support the Gateway Hypothesis. Neuropsychopharmacology 42:1001-1011

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