Calcium and Electrical Oscillations A book was published on modeling in neuroendocrinology, growing out of a series of small intensive workshops that brought together theoreticians and experimentalists. The book was designed to be didactic so as to train young scientists in the techniques and possibilities of this emerging field. We contributed a chapter on calcium oscillations, which may be driven by repetitive releases of calcium from the endoplasmic reticulum or by calcium entry through the plasma membrane (Ref. # 1). The latter usually involves bursts of action potentials, which are more effective at raising cytosolic calcium than maintained spike activity. Both types of oscillations may be present in a single cell type and can interact to produce complex patterns. The chapter emphasizes that a diverse array of models for oscillations in various pituitary cell types as well as in pancreatic beta cells differ from each other only in detail and can be easily transformed into each other. Current efforts include work on a universal pituitary cell model that we hope will shed light on how all the cell types arise from a common precursor during development.
| Fletcher, Patrick A; Sherman, Arthur; Stojilkovic, Stanko S (2018) Common and diverse elements of ion channels and receptors underlying electrical activity in endocrine pituitary cells. Mol Cell Endocrinol 463:23-36 |
| Mackay, Laurent; Zemkova, Hana; Stojilkovic, Stanko S et al. (2017) Deciphering the regulation of P2X4 receptor channel gating by ivermectin using Markov models. PLoS Comput Biol 13:e1005643 |
| Sherman, Arthur S; Ha, Joon (2017) How Adaptation Makes Low Firing Rates Robust. J Math Neurosci 7:4 |
| Fletcher, Patrick A; Zemkova, Hana; Stojilkovic, Stanko S et al. (2017) Modeling the diversity of spontaneous and agonist-induced electrical activity in anterior pituitary corticotrophs. J Neurophysiol 117:2298-2311 |
| Zemkova, Hana; Khadra, Anmar; Rokic, Milos B et al. (2015) Allosteric regulation of the P2X4 receptor channel pore dilation. Pflugers Arch 467:713-26 |
| Khadra, Anmar; Tomic, Melanija; Yan, Zonghe et al. (2013) Dual gating mechanism and function of P2X7 receptor channels. Biophys J 104:2612-21 |
| Khadra, Anmar; Yan, Zonghe; Coddou, Claudio et al. (2012) Gating properties of the P2X2a and P2X2b receptor channels: experiments and mathematical modeling. J Gen Physiol 139:333-48 |
| Matveev, Victor; Bertram, Richard; Sherman, Arthur (2011) Calcium cooperativity of exocytosis as a measure of Caýý+ channel domain overlap. Brain Res 1398:126-38 |
| Yan, Zonghe; Khadra, Anmar; Sherman, Arthur et al. (2011) Calcium-dependent block of P2X7 receptor channel function is allosteric. J Gen Physiol 138:437-52 |
| Tsaneva-Atanasova, Krasimira; Osinga, Hinke M; Riess, Thorsten et al. (2010) Full system bifurcation analysis of endocrine bursting models. J Theor Biol 264:1133-46 |
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