Abstract

Increased oxygen consumption rate observed in primary cultures of erythropoietin stimulated erythroid progenitor cells suggest a link between increased metabolism and erythropoietin stimulated erythropoiesis. In addition, erythropoietin stimulation increases glucose uptake in erythroid progenitor cells without change in fetal hemoglobin. Interestingly, mice (C57Bl6) on high fat diet treated with erythropoietin show the expected increase in hematocrit accompanied by a decrease in blood glucose level. This change in blood glucose is accompanied by an improvement in glucose tolerance and a decrease in cumulated fat mass. In addition to erythropoietin receptor expression in erythroid progenitor cells, erythropoietin receptor is also expressed in white adipose tissue. Deletion of the erythropoietin receptor in white adipose tissue does not alter the hematopoietic response in mice on high fat diet, although the decrease in cumulated fat mass is markedly reduced compared with control mice. These data suggest that the reduction of fat mass with erythropoietin treatment in mice is due in part to the erythropoietin stimulated increase of glucose uptake by erythroid progenitor cells and to erythropoietin response in non-hematopoietic tissue such as white fat.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIADK025021-40
Application #
9148738
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
40
Fiscal Year
2015
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst Diabetes/Digst/Kidney
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

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Cokic, Vladan P; Smith, Reginald D; Biancotto, Angelique et al. (2013) Globin gene expression in correlation with G protein-related genes during erythroid differentiation. BMC Genomics 14:116
Yang, Tao; Jian, Wei; Luo, Yi et al. (2012) Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity. J Biol Chem 287:40279-91
Cokic, Vladan P; Bhattacharya, Bhaskar; Beleslin-Cokic, Bojana B et al. (2012) JAK-STAT and AKT pathway-coupled genes in erythroid progenitor cells through ontogeny. J Transl Med 10:116

Showing the most recent 10 out of 14 publications