1) Continuing our work on exosomes as a source of biomarkers, we found microRNA in human salivary exosomes from patients. MicroRNAs can regulate large numbers of genes post-transcriptionally, which complements our work with transcription factors in exosomes. We continue refinement of both types of promising biomarker candidates in larger sets of patients, as well as in animal models. 2) Serum creatinine is used clinically as a biomarker for acute kidney injury, and we tested the effect of removing the kidneys after sepsis in mice, and we were surprised to find that serum creatinine decreased. This contradicts the expected effect, and we explored possible causes. We found that net production of circulating creatinine is decreased during sepsis. This observation can now explain why such small increases in serum creatinine still underestimate kidney injury in sepsis patients. We continue to delve into the mechanism(s) for this phenomenon.
| Wolfinger, Russell D; Beedanagari, Sudheer; Boitier, Eric et al. (2018) Two approaches for estimating the lower limit of quantitation (LLOQ) of microRNA levels assayed as exploratory biomarkers by RT-qPCR. BMC Biotechnol 18:6 |
| Cai, Yan; Xu, Ming-Jiang; Koritzinsky, Erik H et al. (2017) Mitochondrial DNA-enriched microparticles promote acute-on-chronic alcoholic neutrophilia and hepatotoxicity. JCI Insight 2: |
| Street, J M; Koritzinsky, E H; Glispie, D M et al. (2017) Urine Exosomes: An Emerging Trove of Biomarkers. Adv Clin Chem 78:103-122 |
| Koritzinsky, Erik H; Street, Jonathan M; Star, Robert A et al. (2017) Quantification of Exosomes. J Cell Physiol 232:1587-1590 |
| Street, Jonathan M; Koritzinsky, Erik H; Glispie, Deonna M et al. (2017) Urine Exosome Isolation and Characterization. Methods Mol Biol 1641:413-423 |
| Koritzinsky, Erik H; Street, Jonathan M; Star, Robert A et al. (2017) Cover Image, Volume 232, Number 7, July 2017. J Cell Physiol 232:i |
| Bavendam, Tamara G; Norton, Jenna M; Kirkali, Ziya et al. (2016) Advancing a Comprehensive Approach to the Study of Lower Urinary Tract Symptoms. J Urol 196:1342-1349 |
| Askenazi, David J; Morgan, Catherine; Goldstein, Stuart L et al. (2016) Strategies to improve the understanding of long-term renal consequences after neonatal acute kidney injury. Pediatr Res 79:502-8 |
| Souza, Ana Carolina P; Bocharov, Alexander V; Baranova, Irina N et al. (2016) Antagonism of scavenger receptor CD36 by 5A peptide prevents chronic kidney disease progression in mice independent of blood pressure regulation. Kidney Int 89:809-22 |
| Thompson, Karol L; Boitier, Eric; Chen, Tao et al. (2016) Absolute Measurement of Cardiac Injury-Induced microRNAs in Biofluids across Multiple Test Sites. Toxicol Sci 154:115-125 |
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