Sphingolipid Biology of Inflammation and Immunity

Proia, Richard

Abstract

We are studying the mechanism by which sphingolipids regulate immunity and inflammation. Our focus has been on sphingosine-1-phosphate (S1P), a bioactive lipid enriched in the vascular and lymphatic systems, and the S1P receptors, found on immune cells and the endothelium. Essential roles for S1P and its receptors have been found for immune system development and homeostasis as well as for the regulation of immune responses and inflammation. We are studying the individual roles of the S1P receptors and the sphingolipid metabolic pathway in inflammation and immunity.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIADK056015-08
• Application #: 8939634
• Support Year: 8
• Fiscal Year: 2014

Institution

• Name: U.S. National Inst Diabetes/Digst/Kidney

Publications

Kulinski, Joseph M; Proia, Richard L; Larson, Elisabeth M et al. (2018) S1P? Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells. Int J Mol Sci 19:

Nugent, Adrienne; Proia, Richard L (2017) The role of G protein-coupled receptors in lymphoid malignancies. Cell Signal 39:95-107

Alexaki, Aikaterini; Clarke, Benjamin A; Gavrilova, Oksana et al. (2017) De Novo Sphingolipid Biosynthesis Is Required for Adipocyte Survival and Metabolic Homeostasis. J Biol Chem 292:3929-3939

Kono, Mari; Conlon, Elizabeth G; Lux, Samantha Y et al. (2017) Bioluminescence imaging of G protein-coupled receptor activation in living mice. Nat Commun 8:1163

Xiong, Yuquan; Lee, Hyuek Jong; Mariko, Boubacar et al. (2016) Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem 291:11465

Taguchi, Yoshimitsu; Allende, Maria L; Mizukami, Hiroki et al. (2016) Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet ?-Cell Endoplasmic Reticulum Stress and Proliferation. J Biol Chem 291:12029-38

Proia, Richard L; Hla, Timothy (2015) Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. J Clin Invest 125:1379-87

Kono, Mari; Proia, Richard L (2015) Imaging S1P1 activation in vivo. Exp Cell Res 333:178-82

Galvani, Sylvain; Sanson, Marie; Blaho, Victoria A et al. (2015) HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. Sci Signal 8:ra79

Blaho, Victoria A; Galvani, Sylvain; Engelbrecht, Eric et al. (2015) HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. Nature 523:342-6