Genes associated with endocrine tumorigenesis

Agarwal, Sunita

Abstract

Functional inactivation of menin, encoded by the MEN1 gene, causes the inherited multiple endocrine neoplasia type 1 (MEN1) syndrome and some but not all sporadic pancreatic endocrine tumors. Therefore exploring molecular events upstream or downstream of menin could point to other causative genes and/or regulatory events responsible for such tumor types. Our current efforts are directed towards studying 2 categories of genes for menin-regulated transcriptional, post-transcriptional, protein:protein interaction, and sub-cellular localization events: 1) Cyclin-dependent kinase inhibitors, and 2) Endocrine pancreas differentiation factors.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Investigator-Initiated Intramural Research Projects (ZIA)
• Project #: 1ZIADK075035-01
• Application #: 7967843
• Support Year: 1
• Fiscal Year: 2009
• Total Cost: $927,108

Institution

• Name: National Institute of Diabetes and Digestive and Kidney Diseases

Publications

Parekh, Vaishali I; Modali, Sita D; Welch, James et al. (2018) Frequency and consequence of the recurrent YY1 p.T372R mutation in sporadic insulinomas. Endocr Relat Cancer 25:L31-L35

Thakur, Shilpa; Daley, Brianna; Gaskins, Kelli et al. (2018) Metformin Targets Mitochondrial Glycerophosphate Dehydrogenase to Control Rate of Oxidative Phosphorylation and Growth of Thyroid Cancer In Vitro and In Vivo. Clin Cancer Res 24:4030-4043

Agarwal, Sunita K (2017) The future: genetics advances in MEN1 therapeutic approaches and management strategies. Endocr Relat Cancer 24:T119-T134

Iyer, Sucharitha; Modali, Sita D; Agarwal, Sunita K (2017) Long Noncoding RNA MEG3 Is an Epigenetic Determinant of Oncogenic Signaling in Functional Pancreatic Neuroendocrine Tumor Cells. Mol Cell Biol 37:

Keutgen, Xavier M; Nilubol, Naris; Agarwal, Sunita et al. (2016) Reoperative Surgery in Patients with Multiple Endocrine Neoplasia Type 1 Associated Primary Hyperparathyroidism. Ann Surg Oncol :

Guan, Bin; Welch, James M; Sapp, Julie C et al. (2016) GCM2-Activating Mutations in Familial Isolated Hyperparathyroidism. Am J Hum Genet 99:1034-1044

Parekh, Vaishali I; Modali, Sita D; Desai, Shruti S et al. (2015) Consequence of Menin Deficiency in Mouse Adipocytes Derived by In Vitro Differentiation. Int J Endocrinol 2015:149826

Modali, Sita D; Parekh, Vaishali I; Kebebew, Electron et al. (2015) Epigenetic regulation of the lncRNA MEG3 and its target c-MET in pancreatic neuroendocrine tumors. Mol Endocrinol 29:224-37

Desai, Shruti S; Kharade, Sampada S; Parekh, Vaishali I et al. (2015) Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b). J Biol Chem 290:25595-608

Gara, Sudheer Kumar; Jia, Li; Merino, Maria J et al. (2015) Germline HABP2 Mutation Causing Familial Nonmedullary Thyroid Cancer. N Engl J Med 373:448-55