This year, we provided the first comprehensive comparison of the efficiency of MMR of leading and lagging strand replication errors. We demonstrated that exonuclease 1 preferentially repairs mismatches generated by DNA polymerase alpha. We provided strong evidence that ribonucleotides are signals for mismatch repair of leading strand replication errors. Finally, we collaborated with Winfried Edelmann on a study indicating that mouse Exo1 encodes both structural and catalytic functions that play distinct roles in several essential biological processes.

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Burkholder, Adam B; Lujan, Scott A; Lavender, Christopher A et al. (2018) Muver, a computational framework for accurately calling accumulated mutations. BMC Genomics 19:345
Van, Christopher; Williams, Jessica S; Kunkel, Thomas A et al. (2015) Deposition of histone H2A.Z by the SWR-C remodeling enzyme prevents genome instability. DNA Repair (Amst) 25:9-14
Lujan, Scott A; Clark, Alan B; Kunkel, Thomas A (2015) Differences in genome-wide repeat sequence instability conferred by proofreading and mismatch repair defects. Nucleic Acids Res 43:4067-74
Kunkel, Thomas A; Erie, Dorothy A (2015) Eukaryotic Mismatch Repair in Relation to DNA Replication. Annu Rev Genet 49:291-313
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Liberti, Sascha E; Larrea, Andres A; Kunkel, Thomas A (2013) Exonuclease 1 preferentially repairs mismatches generated by DNA polymerase ?. DNA Repair (Amst) 12:92-6
Jirawatnotai, Siwanon; Hu, Yiduo; Michowski, Wojciech et al. (2011) A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature 474:230-4
Clark, Alan B; Lujan, Scott A; Kissling, Grace E et al. (2011) Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ?. DNA Repair (Amst) 10:476-82

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