The overall goal of the this project is to understand how cells and tissues respond to environmental stress. Glucocorticoids are primary stress response hormones and chronic evaluation of glucocorticoids due to prolonged stress and/or chronic therapeutic intervention can lead to detrimental actions on human health. Thus studying their actions and signaling pathways is critical to the mission of NIEHS. We seek to understand how glucocorticoids signal in a cell specific manner. These hormones regulate multiple aspects of physiology including glucose homeostasis, protein metabolism, skeletal growth, connective tissue metabolism, respiratory function, immune surveillance and components of human behavior. They are essential for life in man.

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Quinn, Matthew A; Xu, Xiaojiang; Ronfani, Melania et al. (2018) Estrogen Deficiency Promotes Hepatic Steatosis via a Glucocorticoid Receptor-Dependent Mechanism in Mice. Cell Rep 22:2690-2701
Cain, Derek W; Cidlowski, John A (2017) Immune regulation by glucocorticoids. Nat Rev Immunol 17:233-247
Oakley, Robert H; Busillo, John M; Cidlowski, John A (2017) Cross-talk between the glucocorticoid receptor and MyoD family inhibitor domain-containing protein provides a new mechanism for generating tissue-specific responses to glucocorticoids. J Biol Chem 292:5825-5844
Whirledge, Shannon; Cidlowski, John A (2017) Glucocorticoids and Reproduction: Traffic Control on the Road to Reproduction. Trends Endocrinol Metab 28:399-415
Busada, Jonathan T; Cidlowski, John A (2017) Mechanisms of Glucocorticoid Action During Development. Curr Top Dev Biol 125:147-170
Jewell, Christine M; Katen, Kevin S; Barber, Lisa M et al. (2016) Healthy Glucocorticoid Receptor N363S Carriers Dysregulate Gene Expression Associated with Metabolic Syndrome. Am J Physiol Endocrinol Metab :ajpendo.00105.2016
Bortner, C D; Scoltock, A B; Cain, D W et al. (2016) T-cell development of resistance to apoptosis is driven by a metabolic shift in carbon source and altered activation of death pathways. Cell Death Differ 23:889-902
Ramamoorthy, Sivapriya; Cidlowski, John A (2016) Corticosteroids: Mechanisms of Action in Health and Disease. Rheum Dis Clin North Am 42:15-31, vii
Regan Anderson, Tarah M; Ma, Shi Hong; Raj, Ganesh V et al. (2016) Breast Tumor Kinase (Brk/PTK6) Is Induced by HIF, Glucocorticoid Receptor, and PELP1-Mediated Stress Signaling in Triple-Negative Breast Cancer. Cancer Res 76:1653-63
Quinn, Matthew A; Cidlowski, John A (2016) Endogenous hepatic glucocorticoid receptor signaling coordinates sex-biased inflammatory gene expression. FASEB J 30:971-82

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