The Host Defense Group of the Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, headed by Michael B. Fessler, MD now enters its 13th year at the NIEHS. Publications since the last annual report include: 1. a collaborative report that CD4 (a T cell gene)-driven expression of the cancer gene K-ras causes an atypical proliferative pneumonitis 2. a collaborative report of the effects of the drug simvastatin on the proteins that bind to the immune receptor TLR2. 3. a collaborative report that the cholesterol transporter ABCG1 suppresses changes in the lung that mimic the disease sarcoidosis 4. a book chapter about research modeling of influenza pneumonia 5. a senior-author paper identifying the protein Lrch4 as a novel receptor that controls inflammation. 6. an editorial on drugs that target the neutrophil in COPD 7. a senior author publication showing that variants of the gene IRGM associate with risk for Crohn's disease 8. a senior author report identifying the lipid cholestenoic acid as a biomarker in acute respiratory distress syndrome. Additional accomplishments since our last report include filing of a patent application by Dr. Fessler on a potential novel strategy for intervening on lung inflammation (No. 62/664,805 (4/30/18)), receipt by Dr. Fessler of a 'Top Reviewer Award' by American Journal of Respiratory Cell and Molecular Biology, appointment of Dr. Fessler as an Associate Editor by the same journal, appointment of Dr. Fessler as a member of the External Advisory Committee of the LSU COBRE program, and presentation of findings from Dr. Fessler's group, in the form of oral presentations and posters, at several national/international meetings.

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Kamal, Abu Hena M; Fessler, Michael B; Chowdhury, Saiful M (2018) Comparative and network-based proteomic analysis of low dose ethanol- and lipopolysaccharide-induced macrophages. PLoS One 13:e0193104
Fessler, Michael B (2018) The challenges and promise of targeting the Liver X Receptors for treatment of inflammatory disease. Pharmacol Ther 181:1-12
Kumar, Ashutosh; Triquigneaux, Mathilde; Madenspacher, Jennifer et al. (2018) Sulfite-induced protein radical formation in LPS aerosol-challenged mice: Implications for sulfite sensitivity in human lung disease. Redox Biol 15:327-334
Fessler, Michael B (2017) A New Frontier in Immunometabolism. Cholesterol in Lung Health and Disease. Ann Am Thorac Soc 14:S399-S405
Fessler, Michael B (2017) CO2 as a Potential Obesogen: A Gas That Will Stick to Your Ribs. Am J Respir Cell Mol Biol 57:499-500
Sakamachi, Yosuke; Morioka, Sho; Mihaly, September R et al. (2017) TAK1 regulates resident macrophages by protecting lysosomal integrity. Cell Death Dis 8:e2598
Suratt, Benjamin T; Ubags, Niki D J; Rastogi, Deepa et al. (2017) An Official American Thoracic Society Workshop Report: Obesity and Metabolism. An Emerging Frontier in Lung Health and Disease. Ann Am Thorac Soc 14:1050-1059
Henderson, Michael W; Madenspacher, Jennifer H; Whitehead, Gregory S et al. (2017) Effects of Orally Ingested Arsenic on Respiratory Epithelial Permeability to Bacteria and Small Molecules in Mice. Environ Health Perspect 125:097024
Azzam, Kathleen M; Madenspacher, Jennifer H; Cain, Derek W et al. (2017) Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces. JCI Insight 2:
Gabor, Kristin A; Fessler, Michael B (2017) Roles of the Mevalonate Pathway and Cholesterol Trafficking in Pulmonary Host Defense. Curr Mol Pharmacol 10:27-45

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