Abstract

In the AGES cohort we are estimating the prevalence and risk factors of eye disease as well investigating possible functional correlates in persons exhibiting clinical signs in other organ systems. A follow-up examination on a subset of 4,000 elderly individuals in this cohort was initiated at the end of 2007 with the examination to run through September 2011. A subgroup of the AGES participants was genotyped in 2009. AGES is a member of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. As such, it is involved in genetic meta-analysis for discovery or replication of genetic variants of disease. For more information on the study, see www.hjarta.is/english/ages. Refer to project bibliography on the study website for published papers and papers in press. See also annual reports AG007380 and AG006000(Dr. Harris).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAEY000401-10
Application #
8339767
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2011
Total Cost
$140,946
Indirect Cost

  Institution

Name
U.S. National Eye Institute
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Xu, Kaipin; Sigurdsson, Sigurdur; Gudnason, Vilmundur et al. (2018) Reliable quantification of marrow fat content and unsaturation level using in vivo MR spectroscopy. Magn Reson Med 79:1722-1729
Qiu, Chengxuan; Ding, Jie; Sigurdsson, Sigurdur et al. (2018) Differential associations between retinal signs and CMBs by location: The AGES-Reykjavik Study. Neurology 90:e142-e148
Sobrin, Lucia; Chong, Yong He; Fan, Qiao et al. (2017) Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Diabetes 66:3130-3141
Gaksch, Martin; Jorde, Rolf; Grimnes, Guri et al. (2017) Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium. PLoS One 12:e0170791
Thordardottir, Marianna; Lindqvist, Ebba K; Lund, Sigrun H et al. (2017) Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study. Blood Adv 1:2186-2192
Telomeres Mendelian Randomization Collaboration; Haycock, Philip C; Burgess, Stephen et al. (2017) Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol 3:636-651
Chu, Audrey Y; Deng, Xuan; Fisher, Virginia A et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nat Genet 49:125-130
Thorsteinsdottir, Sigrun; Lund, Sigrun H; Lindqvist, Ebba K et al. (2017) Bone disease in monoclonal gammopathy of undetermined significance: results from a screened population-based study. Blood Adv 1:2790-2798
Fan, Qiao; Verhoeven, Virginie J M; Wojciechowski, Robert et al. (2016) Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. Nat Commun 7:11008
Fisher, Diana E; Jonasson, Fridbert; Klein, Ronald et al. (2016) Mortality in Older Persons with Retinopathy and Concomitant Health Conditions: The Age, Gene/Environment Susceptibility-Reykjavik Study. Ophthalmology 123:1570-80

Showing the most recent 10 out of 40 publications