In the AGES cohort we are able to assess various profiles of health, disease, and physical function. With respect to the eyes, we are estimating the prevalence and risk factors of eye disease as well investigating possible functional correlates in persons exhibiting clinical signs of disease in other organ systems, including the brain. For example, AGES data confirms that retinopathy lesions are found in older people who do not have diabetes; lesions in persons without diabetes constitute the majority (78%) of retinopathy cases. Usually the retinal lesions are mild. Kidney dysfunction is also likely to be present in affected individuals. AGES is a member of the Cohort for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. As such, it is involved in genetic meta-analysis for discovery or replication of genetic variants of disease. AGES has partnered with international collaborators and published papers on the genetic basis of retinal vessel caliber, retinopathy, and age-related macular degeneration. For more information on the AGES study (design, progress and findings), see Refer to project bibliography on the study website for additional published papers. See also ZIAAG007380 and ZIAG006000(Dr. Harris).

National Institute of Health (NIH)
National Eye Institute (NEI)
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U.S. National Eye Institute
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Xu, Kaipin; Sigurdsson, Sigurdur; Gudnason, Vilmundur et al. (2018) Reliable quantification of marrow fat content and unsaturation level using in vivo MR spectroscopy. Magn Reson Med 79:1722-1729
Qiu, Chengxuan; Ding, Jie; Sigurdsson, Sigurdur et al. (2018) Differential associations between retinal signs and CMBs by location: The AGES-Reykjavik Study. Neurology 90:e142-e148
Thordardottir, Marianna; Lindqvist, Ebba K; Lund, Sigrun H et al. (2017) Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based study. Blood Adv 1:2186-2192
Telomeres Mendelian Randomization Collaboration; Haycock, Philip C; Burgess, Stephen et al. (2017) Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. JAMA Oncol 3:636-651
Chu, Audrey Y; Deng, Xuan; Fisher, Virginia A et al. (2017) Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nat Genet 49:125-130
Thorsteinsdottir, Sigrun; Lund, Sigrun H; Lindqvist, Ebba K et al. (2017) Bone disease in monoclonal gammopathy of undetermined significance: results from a screened population-based study. Blood Adv 1:2790-2798
Sobrin, Lucia; Chong, Yong He; Fan, Qiao et al. (2017) Genetically Determined Plasma Lipid Levels and Risk of Diabetic Retinopathy: A Mendelian Randomization Study. Diabetes 66:3130-3141
Gaksch, Martin; Jorde, Rolf; Grimnes, Guri et al. (2017) Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium. PLoS One 12:e0170791
Cashman, Kevin D; Dowling, Kirsten G; Škrabáková, Zuzana et al. (2016) Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr 103:1033-44
Jensen, Richard A; Sim, Xueling; Smith, Albert Vernon et al. (2016) Novel Genetic Loci Associated With Retinal Microvascular Diameter. Circ Cardiovasc Genet 9:45-54

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