Abstract

We randomly assigned 4589 healthy nulliparous women who were 13 to 21 weeks pregnant to receive daily treatment with either 2g of elemental calcium or placebo for the remainder of their pregnancies. Calcium supplementation did not significantly reduce the incidence or severity of preeclampsia or delay its onset. Additional analyses utilizing the study database and specimen repository are being performed. During FY09 papers were published or are currently in press on the relationship of preeclampsia and soluble fms-like tyrosine kinase 1 to the development of reduced thyroid function, the correlation of angiogenic factor abnormalities with spontanaeous resolution of preeclampsia following intrauterine death of one twin, on first rimestser prediction of early preeclampsia, on circulating angiogenic factors in gestational proteinuria without hypertension, and on the use of angiogenic biomarkers to distinguish non-HELLP related thrombocytopenia from HELLP syndrome. Work on angiogenic factors and preeclampsia is continuing.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAHD000373-21
Application #
7968497
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
2009
Total Cost
$229,530
Indirect Cost

  Institution

Name
Eunice Kennedy Shriver National Institute of Child Health & Human Development
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Boghossian, Nansi S; Koo, Winston; Liu, Aiyi et al. (2018) Longitudinal measures of maternal vitamin D and neonatal body composition. Eur J Clin Nutr :
Boghossian, N S; Mendola, P; Liu, A et al. (2017) Maternal serum markers of lipid metabolism in relation to neonatal anthropometry. J Perinatol 37:629-635
Mendola, Pauline; Ghassabian, Akhgar; Mills, James L et al. (2017) Retinol-Binding Protein 4 and Lipids Prospectively Measured During Early to Mid-Pregnancy in Relation to Preeclampsia and Preterm Birth Risk. Am J Hypertens 30:569-576
Yeung, Edwina H; Liu, Aiyi; Mills, James L et al. (2014) Increased levels of copeptin before clinical diagnosis of preeclampsia. Hypertension 64:1362-7
Young, Brett; Levine, Richard J; Salahuddin, Saira et al. (2010) The use of angiogenic biomarkers to differentiate non-HELLP related thrombocytopenia from HELLP syndrome. J Matern Fetal Neonatal Med 23:366-70
Young, Brett C; Levine, Richard J; Karumanchi, S Ananth (2010) Pathogenesis of preeclampsia. Annu Rev Pathol 5:173-92
Lynch, A M; Murphy, J R; Gibbs, R S et al. (2010) The interrelationship of complement-activation fragments and angiogenesis-related factors in early pregnancy and their association with pre-eclampsia. BJOG 117:456-62
Karumanchi, S Ananth; Levine, Richard J (2010) How does smoking reduce the risk of preeclampsia? Hypertension 55:1100-1
Levine, Richard J; Vatten, Lars J; Horowitz, Gary L et al. (2009) Pre-eclampsia, soluble fms-like tyrosine kinase 1, and the risk of reduced thyroid function: nested case-control and population based study. BMJ 339:b4336
Klebanoff, Mark A; Zhang, Jun; Zhang, Cuilin et al. (2009) Maternal serum theobromine and the development of preeclampsia. Epidemiology 20:727-32

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