Abstract

In the past year investigators and staff on this project proposed a repeated significance tests procedure for linear combinations of sensitivity and specificity of a diagnostic biomarker; Investigated linear combination methods to improve diagnostic/prognostic accuracy on future observations; Developed a method to maximize an ROC-type measure via linear combinations of biomarkers; Developed method for estimation of a diagnostic accuracy index of a diagnostic biomarker when the reference gold standard is continuous and measured with error.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAHD008875-09
Application #
9550408
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst/Child Hlth/Human Dev
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Gee, B T; Nansel, T R; Liu, A (2017) Reduction of hypoglycaemic events with a behavioural intervention: a randomized clinical trial for paediatric patients with Type 1 diabetes mellitus. Diabet Med 34:340-347
Yin, Lixuan; Diao, Guoqing; Liu, Aiyi (2017) A semiparametric method for comparing the discriminatory ability of biomarkers subject to limit of detection. Stat Med 36:4141-4152
Zhang, Wei; Yang, Liu; Tang, Larry L et al. (2017) GATE: an efficient procedure in study of pleiotropic genetic associations. BMC Genomics 18:552
Nansel, Tonja R; Lipsky, Leah M; Liu, Aiyi (2016) Greater diet quality is associated with more optimal glycemic control in a longitudinal study of youth with type 1 diabetes. Am J Clin Nutr 104:81-7
Wu, Mixia; Zhang, Dianchen; Liu, Aiyi (2016) Estimation of an accuracy index of a diagnostic biomarker when the reference biomarker is continuous and measured with error. J Biopharm Stat 26:1111-1117
Li, Shanshan; Zhu, Yeyi; Chavarro, Jorge E et al. (2016) Healthful Dietary Patterns and the Risk of Hypertension Among Women With a History of Gestational Diabetes Mellitus: A Prospective Cohort Study. Hypertension 67:1157-65
Liu, Aiyi; Yue, Lilly Q (2016) A conversation with Dr. Greg Campbell. J Biopharm Stat 26:1007-1019
Lipsky, Leah M; Gee, Benjamin; Liu, Aiyi et al. (2016) Glycemic control and variability in association with body mass index and body composition over 18months in youth with type 1 diabetes. Diabetes Res Clin Pract 120:97-103
Boghossian, Nansi S; Sicko, Robert J; Kay, Denise M et al. (2016) Rare copy number variants implicated in posterior urethral valves. Am J Med Genet A 170:622-33
Kang, Le; Liu, Aiyi; Tian, Lili (2016) Linear combination methods to improve diagnostic/prognostic accuracy on future observations. Stat Methods Med Res 25:1359-80

Showing the most recent 10 out of 44 publications