This project is motivated by various pregnancy studies that have been conducted and are being conducted at DESPR. These include the New York State Angler Cohort Prospective Pregnancy Study, The Impact of Physiologic and Perceived Psychosocial Stress on Time to Pregnancy and the Longitudinal Investigation of Fertility and the Environment (LIFE) Study (PI, Dr G. Buck Louis of Epidemiology Branch). Fecundability (Gini, 1926) is defined as the probability of conception in a menstrual cycle for couples having regular sexual intercourse without contraception. Reproductive epidemiologists are interested in models for human fecundity to identify the determinants and causes of reproductive dysfunction. There is also suspicion that various environmental factors negatively affect the human fertility. Despite extensive efforts (ex., Weinberg and Gladen (1986), Zhou and others (1996), Scheike and Jensen (1997), Dunson and Zhou (1997), Dunson and Stanford (2005) to name a few), modeling fecundability data remains a statistically challenging task. Indeed, as modeling of fecundability stepped from demography and population-based contexts to reproductive biology and treatment of infertility, the new situation created a strong call for: 1) flexibility, because of the important and ever increasing quantity of information researchers collect;and 2) robustness, because of the potential crude interpretations of the estimated effects and the resulting important decisions in everyday medical practice. Two main sources of heterogeneity effecting fecundability are biological and behavioral. This distinction does not preclude potential interactions between these two factors. For example, both womans length of window of fertility and mans length of life of sperm, which are biological factors, modify the effect of intercourse-pattern on the probability of conception. Several elements have been studied and confirmed as factors of impaired fecundability, such as advanced age or exposure to a toxic substance. However, most of the biological heterogeneity remains unexplained. Similarly, the explained part of the effect of intercourse pattern on fecundability includes the number and timing of intercourse on particular days in relation to ovulation, the quality of cervical mucus and the use of local contraceptives. Nevertheless, the magnitude of the unexplained heterogeneity may be at least as important as the effects of the covariates. The research focus of Dr Sundaram and her collaborators are to account for various measurement errors encountered in observing biological factors and to develop joint modeling approach for intercourse pattern and fecundability as assuming the intercourse pattern to be fixed may not be reasonable and they both share common risk factors, like advanced age, parity (previous child birth) and may be influenced by underlying hormonal levels in both male and female. Some of the projects that have been completed or are in completion stage are listed below:

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Lum, Kirsten J; Sundaram, Rajeshwari; Barr, Dana B et al. (2017) Perfluoroalkyl Chemicals, Menstrual Cycle Length, and Fecundity: Findings from a Prospective Pregnancy Study. Epidemiology 28:90-98
Sundaram, Rajeshwari; Mumford, Sunni L; Buck Louis, Germaine M (2017) Couples' body composition and time-to-pregnancy. Hum Reprod 32:662-668
Robledo, Candace A; Yeung, Edwina H; Mendola, Pauline et al. (2017) Examining the Prevalence Rates of Preexisting Maternal Medical Conditions and Pregnancy Complications by Source: Evidence to Inform Maternal and Child Research. Matern Child Health J 21:852-862
Yeung, Edwina H; Sundaram, Rajeshwari; Ghassabian, Akhgar et al. (2017) Parental Obesity and Early Childhood Development. Pediatrics 139:
Louis, Germaine M Buck; Sapra, Katherine J; Barr, Dana Boyd et al. (2016) Preconception perfluoroalkyl and polyfluoroalkyl substances and incident pregnancy loss, LIFE Study. Reprod Toxicol 65:11-17
Smarr, Melissa M; Grantz, Katherine L; Sundaram, Rajeshwari et al. (2016) Urinary paracetamol and time-to-pregnancy. Hum Reprod 31:2119-27
Buck Louis, G M; Barr, D B; Kannan, K et al. (2016) Paternal exposures to environmental chemicals and time-to-pregnancy: overview of results from the LIFE study. Andrology 4:639-47
Smarr, Melissa M; Grantz, Katherine L; Zhang, Cuilin et al. (2016) Persistent organic pollutants and pregnancy complications. Sci Total Environ 551-552:285-91
Jaacks, Lindsay M; Barr, Dana Boyd; Sundaram, Rajeshwari et al. (2016) Pre-pregnancy maternal exposure to polybrominated and polychlorinated biphenyls and gestational diabetes: a prospective cohort study. Environ Health 15:11
Buck Louis, Germaine M; Sapra, Katherine J; Schisterman, Enrique F et al. (2016) Lifestyle and pregnancy loss in a contemporary cohort of women recruited before conception: The LIFE Study. Fertil Steril 106:180-188

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