The primary goal of this research is to identify significant modifiable factors (i.e., diet, lifestyle factors, etc.) and novel risk factors that may predict the risk for GDM and contribute to the prevention of GDM. Within the common theme of insulin resistance and secretion, several important diet and lifestyle associations with GDM have been successfully identified in this effort based on data from the Nurses Health Study II. Several studies on other modifiable risk factors and other novel risk factors are underway based on the Nurses'Health Study and other collaborative studies. In the past year, we have identified several new risk factors including dietary iron inatkes, life course weight characteristics, sugar sweetened beverage consumption, early age for menarche, etc. These papers were presented in the Annual Scientific Meeting of American Diabetes Association, Society for Epidemiologic Research, and Society for Pediatric and Perinatal Research. We published several papers on this topic as well.

Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2011
Total Cost
$50,000
Indirect Cost
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State
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Bao, Wei; Song, Yiqing; Bertrand, Kimberly A et al. (2018) Prepregnancy habitual intake of vitamin D from diet and supplements in relation to risk of gestational diabetes mellitus: A prospective cohort study. J Diabetes 10:373-379
Bao, Wei; Dar, Sharon; Zhu, Yeyi et al. (2018) Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study. J Diabetes 10:487-495
Rawal, Shristi; Tsai, Michael Y; Hinkle, Stefanie N et al. (2018) A Longitudinal Study of Thyroid Markers Across Pregnancy and the Risk of Gestational Diabetes. J Clin Endocrinol Metab 103:2447-2456
Zhu, Yeyi; Tsai, Michael Y; Sun, Qi et al. (2018) A prospective and longitudinal study of plasma phospholipid saturated fatty acid profile in relation to cardiometabolic biomarkers and the risk of gestational diabetes. Am J Clin Nutr 107:1017-1026
Hinkle, Stefanie N; Tsai, Michael Y; Rawal, Shristi et al. (2018) HbA1c Measured in the First Trimester of Pregnancy and the Association with Gestational Diabetes. Sci Rep 8:12249
Zhang, Cuilin; Rawal, Shristi (2017) Dietary iron intake, iron status, and gestational diabetes. Am J Clin Nutr 106:1672S-1680S
Jaacks, Lindsay M; Barr, Dana Boyd; Sundaram, Rajeshwari et al. (2016) Pre-pregnancy maternal exposure to polybrominated and polychlorinated biphenyls and gestational diabetes: a prospective cohort study. Environ Health 15:11
Chen, Liwei; Li, Shanshan; He, Chunyan et al. (2016) Age at Menarche and Risk of Gestational Diabetes Mellitus: A Prospective Cohort Study Among 27,482 Women. Diabetes Care 39:469-71
Zhang, Cuilin; Rawal, Shristi; Chong, Yap Seng (2016) Risk factors for gestational diabetes: is prevention possible? Diabetologia 59:1385-1390
Bao, Wei; Tobias, Deirdre K; Hu, Frank B et al. (2016) Pre-pregnancy potato consumption and risk of gestational diabetes mellitus: prospective cohort study. BMJ 352:h6898

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