Abstract

The primary goal of this research is to identify significant modifiable factors (i.e., diet, lifestyle factors, etc.) and novel risk factors that may predict the risk for GDM and contribute to the prevention of GDM. Within the common theme of insulin resistance and secretion, several important diet and lifestyle associations with GDM have been successfully identified in this effort based on data from the Nurses' Health Study II and the NICHD Fetal Growth Studies. In the past year, we have identified several new risk factors including dietary protein intakes, potato consumption, history of infertility, history of depression, sleep duration, and environmental chemicals such as perfluorooctanoic acid etc. These papers were presented in the Society of Maternal and Fetal Medicine meeting, Annual Scientific Meeting of American Diabetes Association, Society for Epidemiologic Research, and Society for Pediatric and Perinatal Research. We published several important papers on this topic as well. Several papers are submitted and under review.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAHD008889-09
Application #
9550421
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
U.S. National Inst/Child Hlth/Human Dev
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Bao, Wei; Song, Yiqing; Bertrand, Kimberly A et al. (2018) Prepregnancy habitual intake of vitamin D from diet and supplements in relation to risk of gestational diabetes mellitus: A prospective cohort study. J Diabetes 10:373-379
Bao, Wei; Dar, Sharon; Zhu, Yeyi et al. (2018) Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: A longitudinal study. J Diabetes 10:487-495
Rawal, Shristi; Tsai, Michael Y; Hinkle, Stefanie N et al. (2018) A Longitudinal Study of Thyroid Markers Across Pregnancy and the Risk of Gestational Diabetes. J Clin Endocrinol Metab 103:2447-2456
Zhu, Yeyi; Tsai, Michael Y; Sun, Qi et al. (2018) A prospective and longitudinal study of plasma phospholipid saturated fatty acid profile in relation to cardiometabolic biomarkers and the risk of gestational diabetes. Am J Clin Nutr 107:1017-1026
Hinkle, Stefanie N; Tsai, Michael Y; Rawal, Shristi et al. (2018) HbA1c Measured in the First Trimester of Pregnancy and the Association with Gestational Diabetes. Sci Rep 8:12249
Zhang, Cuilin; Rawal, Shristi (2017) Dietary iron intake, iron status, and gestational diabetes. Am J Clin Nutr 106:1672S-1680S
Zhang, Cuilin; Rawal, Shristi; Chong, Yap Seng (2016) Risk factors for gestational diabetes: is prevention possible? Diabetologia 59:1385-1390
Bao, Wei; Tobias, Deirdre K; Hu, Frank B et al. (2016) Pre-pregnancy potato consumption and risk of gestational diabetes mellitus: prospective cohort study. BMJ 352:h6898
Smarr, Melissa M; Grantz, Katherine L; Zhang, Cuilin et al. (2016) Persistent organic pollutants and pregnancy complications. Sci Total Environ 551-552:285-91
Mason, Susan M; Tobias, Deirdre K; Clark, Cari J et al. (2016) Abuse in Childhood or Adolescence and Gestational Diabetes: A Retrospective Cohort Study. Am J Prev Med 50:436-444

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