During the past year we have continued to collect anonymized tissue specimens for our research. Our bank currently consists of tumor and normal tissues from 118 patients with non-endometrioid forms of endometrial cancer and, for comparative purposes, tissues from 134 endometrioid endometrial cancer patients. We have initiated genetic screens to search for mutations within more than one hundred potential cancer-causing genes among our series of non-endometrioid endometrial tumors. In so doing, we have validated and extended our knowledge of the spectrum of mutations that contribute to the development of this form of malignancy. We are also actively searching for losses and gains of genetic material throughout the entire genome of these tumors, using sophisticated array-based technologies, in conjunction with the NHGRI genomics core.

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National Human Genome Research Institute
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Le Gallo, Matthieu; Rudd, Meghan L; Urick, Mary Ellen et al. (2018) The FOXA2 transcription factor is frequently somatically mutated in uterine carcinosarcomas and carcinomas. Cancer 124:65-73
Urick, Mary Ellen; Bell, Daphne W (2018) In vitro effects of FBXW7 mutation in serous endometrial cancer: Increased levels of potentially druggable proteins and sensitivity to SI-2 and dinaciclib. Mol Carcinog 57:1445-1457
Le Gallo, Matthieu; Rudd, Meghan L; Urick, Mary Ellen et al. (2017) Somatic mutation profiles of clear cell endometrial tumors revealed by whole exome and targeted gene sequencing. Cancer 123:3261-3268
Felix, Ashley S; Yang, Hannah P; Bell, Daphne W et al. (2017) Epidemiology of Endometrial Carcinoma: Etiologic Importance of Hormonal and Metabolic Influences. Adv Exp Med Biol 943:3-46
Le Gallo, Matthieu; Lozy, Fred; Bell, Daphne W (2017) Next-Generation Sequencing. Adv Exp Med Biol 943:119-148
Margolin, Gennady; Petrykowska, Hanna M; Jameel, Nader et al. (2016) Robust Detection of DNA Hypermethylation of ZNF154 as a Pan-Cancer Locus with in Silico Modeling for Blood-Based Diagnostic Development. J Mol Diagn 18:283-98
Hong, Bo; Le Gallo, Matthieu; Bell, Daphne W (2015) The mutational landscape of endometrial cancer. Curr Opin Genet Dev 30:25-31
Price, Jessica C; Pollock, Lana M; Rudd, Meghan L et al. (2014) Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A. PLoS One 8:e63313
Rudd, Meghan L; Mohamed, Hassan; Price, Jessica C et al. (2014) Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1. BMC Cancer 14:884
Bell, Daphne W (2014) Novel genetic targets in endometrial cancer. Expert Opin Ther Targets 18:725-30

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