Abstract

In the past year, we have continued to use both commercially available and unique mouse strains that we have developed to investigate the association between lipoprotein metabolism and atherosclerosis. We completed and published 2 studies related to the role of LCAT and atherosclerosis, using our mouse models. In one study, we showed by creating 3 mouse lines with various levels of LCAT, that amount of free cholesterol in lipoproteins was positively associated with atherosclerosis. By injecting LpX into LCAT-KO mice, we demonstrated in another study that LpX accumulates in the kidney and is nephrotoxic. We also completed and published 2 studies on the effect of fish oils on mouse atherosclerosis. In one study, we showed that adding aspirin potentiates the beneficial effects of fish oils on lipoprotein metabolism and atherosclerosis. In another mouse study, we showed for the first time that long chain monounsaturated fatty (chain lengths greater than 20 carbons) that are enriched in some fish oils, has a beneficial effect in reducing the extent of atherosclerosis when mice are placed on a high fat diet.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAHL002058-21
Application #
9354112
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
U.S. National Heart Lung and Blood Inst
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Li, Dan; Fawaz, Maria V; Morin, Emily E et al. (2018) Effect of Synthetic High Density Lipoproteins Modification with Polyethylene Glycol on Pharmacokinetics and Pharmacodynamics. Mol Pharm 15:83-96
Liu, Yudong; Carmona-Rivera, Carmelo; Moore, Erica et al. (2018) Myeloid-Specific Deletion of Peptidylarginine Deiminase 4 Mitigates Atherosclerosis. Front Immunol 9:1680
Liu, Chao; Han, Tianxu; Stachura, David L et al. (2018) Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply. Nat Commun 9:1310
Yang, Zhi-Hong; Gordon, Scott M; Sviridov, Denis et al. (2017) Dietary supplementation with long-chain monounsaturated fatty acid isomers decreases atherosclerosis and alters lipoprotein proteomes in LDLr(-/-) mice. Atherosclerosis 262:31-38
Baranova, Irina N; Souza, Ana C P; Bocharov, Alexander V et al. (2017) Human SR-BII mediates SAA uptake and contributes to SAA pro-inflammatory signaling in vitro and in vivo. PLoS One 12:e0175824
Couchie, Dominique; Vaisman, Boris; Abderrazak, Amna et al. (2017) Human Plasma Thioredoxin-80 Increases With Age and in ApoE-/- Mice Induces Inflammation, Angiogenesis, and Atherosclerosis. Circulation 136:464-475
Gordon, Scott M; Remaley, Alan T (2017) High density lipoproteins are modulators of protease activity: Implications in inflammation, complement activation, and atherothrombosis. Atherosclerosis 259:104-113
Furumoto, Yasuko; Smith, Carolyne K; Blanco, Luz et al. (2017) Tofacitinib Ameliorates Murine Lupus and Its Associated Vascular Dysfunction. Arthritis Rheumatol 69:148-160
Sakurai, Toshihiro; Sakurai, Akiko; Chen, Ye et al. (2017) Dietary ?-cyclodextrin reduces atherosclerosis and modifies gut flora in apolipoprotein E-deficient mice. Mol Nutr Food Res 61:
Ahmad, Faiyaz; Chung, Youn Wook; Tang, Yan et al. (2016) Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. Sci Rep 6:28056

Showing the most recent 10 out of 46 publications