This year, under this project we developed a new form of x-ray imaging system capable of detecting the refractive bending of x-rays at sub-nanoradian resolution. It is based on the nanometric x-ray gratings we have developed in the recent past. This type of imager can potentially see structures that are transparent to conventional x-ray machines. In the past such sensitivity has been achieved with special x-ray sources of very narrow bandwidths. With the new system the restrictions on the bandwidth and collimation of the x-ray beam are removed, which advances the concept towards compact systems for benchtop pre-clinical applications.

Project Start
Project End
Budget Start
Budget End
Support Year
17
Fiscal Year
2013
Total Cost
$1,137,240
Indirect Cost
Name
National Heart, Lung, and Blood Institute
Department
Type
DUNS #
City
State
Country
Zip Code
George, Alex; Chen, Peter Y; Morales-Martinez, Alejandro et al. (2017) Geometric calibration and correction for a lens-coupled detector in x-ray phase-contrast imaging. J Med Imaging (Bellingham) 4:013507
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Miao, Houxun; Chen, Lei; Mirzaeimoghri, Mona et al. (2016) Cryogenic Etching of High Aspect Ratio 400 nm Pitch Silicon Gratings. J Microelectromech Syst 25:963-967
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Miao, Houxun; Gomella, Andrew A; Chedid, Nicholas et al. (2014) Fabrication of 200 nm period hard X-ray phase gratings. Nano Lett 14:3453-8
Wen, Han; Wolfe, Douglas E; Gomella, Andrew A et al. (2013) Interferometric hard x-ray phase contrast imaging at 204 nm grating period. Rev Sci Instrum 84:013706

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