Abstract

--We continued our studies of the CA2 region of the hippocampus where the Oxtr and Avpr1b are located. The CA2 area is an important, although relatively unexplored, component of the hippocampus. We are studying the role of various receptors and in the CA2 by crossing floxed receptor lines with Oxtr and Avpr1b-cre expressing lines. We are studying the resultant behaviors, especially as they relate to aggression and learning and memory. --We are continuing to use optogenetics and expanding to electrophysiology to study the role of the CA2 in behavior. We are examining the input to CA2 from other regions as well.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Investigator-Initiated Intramural Research Projects (ZIA)
Project #
1ZIAMH002498-29
Application #
9790784
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
29
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
City
State
Country
Zip Code

  Publications

Young, W Scott; Song, June; Mezey, Éva (2018) Hybridization Histochemistry of Neural Transcripts. Curr Protoc Neurosci 82:1.3.1-1.3.27
Mayer, Balázs; Németh, Krisztián; Krepuska, Miklós et al. (2017) Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia. Sci Transl Med 9:
Oettl, Lars-Lennart; Ravi, Namasivayam; Schneider, Miriam et al. (2016) Oxytocin Enhances Social Recognition by Modulating Cortical Control of Early Olfactory Processing. Neuron 90:609-21
Young, W Scott; Song, June; Mezey, Éva (2016) Hybridization Histochemistry of Neural Transcripts. Curr Protoc Neurosci 75:1.3.1-1.3.27
Patial, Sonika; Stumpo, Deborah J; Young 3rd, W Scott et al. (2016) Effects of Combined Tristetraprolin/Tumor Necrosis Factor Receptor Deficiency on the Splenic Transcriptome. Mol Cell Biol 36:1395-411
Smith, A S; Williams Avram, S K; Cymerblit-Sabba, A et al. (2016) Targeted activation of the hippocampal CA2 area strongly enhances social memory. Mol Psychiatry 21:1137-44
Pagani, J H; Zhao, M; Cui, Z et al. (2015) Role of the vasopressin 1b receptor in rodent aggressive behavior and synaptic plasticity in hippocampal area CA2. Mol Psychiatry 20:490-9
Pagani, J H; Williams Avram, S K; Cui, Z et al. (2015) Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxiety-like behavior in male mice only. Genes Brain Behav 14:167-76
Choi, Ji-Woong; Kang, Sung-Min; Lee, Youngkyun et al. (2013) MicroRNA profiling in the mouse hypothalamus reveals oxytocin-regulating microRNA. J Neurochem 126:331-7
Young, W Scott (2013) Shedding heat on oxytocin. Endocrinology 154:3961-2

Showing the most recent 10 out of 26 publications