During the first year of this new project we have completed data collection and preliminary analyses on several behavioral and fMRI studies of communication skills, face and object perception, and understanding of social interactions in high-functioning ASD individuals. Preliminary analyses of the behavioral studies show that these individuals have difficulty perceiving specific emotional states from faces. They also have poor memory for faces relative to another object category of similar overall shape and complexity as faces (electric fans). However, contrary to some previous claims, this face-processing deficit was not attributed to an aversion for looking at the eyes relative to other facial features. Rather, the ASD subjects tend to look less at the global shape of the face than do normally developing control subjects. Consistent with these behavioral findings, our brain imaging data suggest that although the face processing network responds normally to the presentation of photographs of faces in ASD, this system is not utilized normally for more complex processing tasks. For example, whereas normally developing individuals engaged the face processing network when performing tasks requiring understanding of social interactions, the ASD subjects do not. Rather these subjects engage this network regardless of whether the task requires understanding of social or mechanical interactions. One interpretation of these findings is that ASD may be characterized by deficient functional neural connectivity within specific nodes of a processing network. Preliminary analysis of our verbal fluency data, as well as evaluation of functional connectivity during the resting state, supports this possibility.

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Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2009
Total Cost
$1,335,493
Indirect Cost
Name
U.S. National Institute of Mental Health
Department
Type
DUNS #
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Zip Code
Ratto, Allison B; Kenworthy, Lauren; Yerys, Benjamin E et al. (2018) What About the Girls? Sex-Based Differences in Autistic Traits and Adaptive Skills. J Autism Dev Disord 48:1698-1711
Crutcher, Jason; Martin, Alex; Wallace, Gregory L (2018) Dissociations in the neural substrates of language and social functioning in autism spectrum disorder. Autism Res 11:1175-1186
Power, Jonathan D; Plitt, Mark; Gotts, Stephen J et al. (2018) Ridding fMRI data of motion-related influences: Removal of signals with distinct spatial and physical bases in multiecho data. Proc Natl Acad Sci U S A 115:E2105-E2114
Avery, Jason A; Ingeholm, John E; Wohltjen, Sophie et al. (2018) Neural correlates of taste reactivity in autism spectrum disorder. Neuroimage Clin 19:38-46
White, Emily I; Wallace, Gregory L; Bascom, Julia et al. (2017) Sex differences in parent-reported executive functioning and adaptive behavior in children and young adults with autism spectrum disorder. Autism Res 10:1653-1662
Kraper, Catherine K; Kenworthy, Lauren; Popal, Haroon et al. (2017) The Gap Between Adaptive Behavior and Intelligence in Autism Persists into Young Adulthood and is Linked to Psychiatric Co-morbidities. J Autism Dev Disord 47:3007-3017
Power, Jonathan D; Plitt, Mark; Kundu, Prantik et al. (2017) Temporal interpolation alters motion in fMRI scans: Magnitudes and consequences for artifact detection. PLoS One 12:e0182939
Ghuman, Avniel Singh; van den Honert, Rebecca N; Huppert, Theodore J et al. (2017) Aberrant Oscillatory Synchrony Is Biased Toward Specific Frequencies and Processing Domains in the Autistic Brain. Biol Psychiatry Cogn Neurosci Neuroimaging 2:245-252
Power, Jonathan D (2017) A simple but useful way to assess fMRI scan qualities. Neuroimage 154:150-158
Wallace, Gregory L; Dudley, Katerina; Anthony, Laura et al. (2017) Divergence of Age-Related Differences in Social-Communication: Improvements for Typically Developing Youth but Declines for Youth with Autism Spectrum Disorder. J Autism Dev Disord 47:472-479

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